| Identification | Back Directory | [Name]
Talniflumate | [CAS]
66898-62-2 | [Synonyms]
somalgen
ba7602-06
TALNIFLUMATE
Talniflumate, >=99%
Talniflumate (BA 7602-06)
TALNIFLUMATE(INTERMEDIATE)
phthalidyl2-(3-trifluoromethylanilino)nicotinate
2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid phthalidyl ester
phthalidyl2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinate
2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinicacidphthalidylester
2-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinicaciphthalidylester
3-ftalidilicodelacido2-((3-(trifluormetil)fenil)amino)-3-piridincarboxilic
3-phthalidylesterof2-((3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxyl
(3-oxo-1H-2-benzofuran-1-yl) 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate
2-[[3-(Trifluoromethyl)phenyl]amino]nicotinic acid 1,3-dihydro-3-oxoisobenzofuran-1-yl ester
2-[3-(trifluoromethyl)anilino]-3-pyridinecarboxylic acid (3-oxo-1H-isobenzofuran-1-yl) ester
2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl3-pyridinecarboxylicacidester
3-pyridinecarboxylic acid 2-{[(3-trifluoromethyl)phenyl]amino}-1,3-dihydro-3-oxo-1-soenzofuranyl ester
2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO]-3-PYRIDINECARBOXYLIC ACID 1,3-DIHYDRO-3-OXO-1-ISOBENZOFURANYL ESTER
3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C21H13F3N2O4 | [MDL Number]
MFCD00866135 | [MOL File]
66898-62-2.mol | [Molecular Weight]
414.33 |
| Chemical Properties | Back Directory | [Melting point ]
165-167°C | [Boiling point ]
534.6±50.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Chlorform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
2.72±0.10(Predicted) | [color ]
Off-White to Pale Yellow | [λmax]
287nm(CHCl3)(lit.) | [Merck ]
14,9044 | [Stability:]
Acid Sensitive, Moisture Sensitive | [InChI]
InChI=1S/C21H13F3N2O4/c22-21(23,24)12-5-3-6-13(11-12)26-17-16(9-4-10-25-17)19(28)30-20-15-8-2-1-7-14(15)18(27)29-20/h1-11,20H,(H,25,26) | [InChIKey]
ANMLJLFWUCQGKZ-UHFFFAOYSA-N | [SMILES]
C1(NC2=CC=CC(C(F)(F)F)=C2)=NC=CC=C1C(OC1C2=C(C=CC=C2)C(=O)O1)=O |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [RTECS ]
QT2999200 | [HS Code ]
2933.39.9200 | [Storage Class]
11 - Combustible Solids | [Toxicity]
LD50 orally in rats: 12000 mg/kg (Los) |
| Hazard Information | Back Directory | [Chemical Properties]
White to pale yellow crystalline powder | [Originator]
Somalgen,Bago,Argentina,1972 | [Uses]
Anti-inflammatory; analgesic. | [Definition]
ChEBI: 2-[3-(trifluoromethyl)anilino]-3-pyridinecarboxylic acid (3-oxo-1H-isobenzofuran-1-yl) ester is a member of benzofurans. | [Manufacturing Process]
49 ml of triethylamine were added to a suspension of 2-(3'-
trifluoromethylanilino)nicotinic acid (70.6 g in 250 ml of dimethylformamide).
After stirring for 30 minutes 53.3 g of 3-bromophthalide were added. The
reaction mixture was maintained at 25°C to 30°C during 4 hours. Ethyl
acetate (750 ml) was poured into the reaction mixture. This solution was
filtered and extracted with water (4 x 250 ml), discarding the water layer.
The organic layer was dried with anhydrous magnesium sulfate and then
filtered. The solution was concentrated under vacuum at 30°C to 35°C until
reduced to half of its original volume and then cooled to 5°C to allow the
crystallization of the compound. Thus, the cake was filtered, washed with cool
ethyl acetate, and dried under vacuum. Yield: 74% (76.7 g) of phthalidyl
ester of 2-(3'-trifluoromethylanilino)-pyridin-3-carboxylic acid, melting point:
165°C to 167°C. | [Brand name]
Somalgen (Laboratorio Bago, S.A., Argentina). | [Therapeutic Function]
Antiinflammatory, Analgesic | [Biological Activity]
Calcium-activated chloride channel (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl - /HCO 3 - exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome. |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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