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675122-44-8

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675122-44-8 Structure

675122-44-8 Structure

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[Name] BMS639623
[CAS] 675122-44-8
[Synonyms] BMS639623 PON9OFP69G CHEMBL399495 UNII-PON9OFP69G Urea, N-[(1R,2S)-3-[(3S)-3-[(4-fluorophenyl)methyl]-1-piperidinyl]-2-hydroxy-1-methylpropyl]-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]-
[Molecular Formula] C25H32FN7O2
[MOL File] 675122-44-8.mol
[Molecular Weight] 481.57

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[density ] 1.33±0.1 g/cm3(Predicted)
[pka] 13.03±0.46(Predicted)

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[Uses] BMS-639623 is a potent and orally activeCCR3 antagonist with an IC50 of 0.3 nM. BMS-639623 picomolar inhibition potency against eosinophil chemotaxis (IC50=38 pM). BMS-639623 can be used for the research of asthma[1].
[IC 50] CCR3: 0.3 nM (IC₅₀)
[References] [1] Santella JB 3rd, et al. From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis. Bioorg Med Che DOI:10.1016/j.bmcl.2007.11.067

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Company Name:	TargetMol Chemicals Inc.
Telephone:	15002134094
Website:	https://www.targetmol.cn/

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