| Identification | Back Directory | [Name]
3-epi-Zaluzanin C | [CAS]
67667-64-5 | [Synonyms]
Isozaluzanin C
3-Epizaluzanin C
3-epi-Zaluzanin C
(3aS,6aβ,9aβ,9bα)-Decahydro-3,6,9-trismethylene-8β-hydroxyazuleno[4,5-b]furan-2(3H)-one
(3aβ,6aβ,9aβ,9bα)-Decahydro-8β-hydroxy-3,6,9-trismethyleneazuleno[4,5-b]furan-2(3H)-one
Azuleno[4,5-b]furan-2(3H)-one, decahydro-8-hydroxy-3,6,9-tris(methylene)-, (3aS,6aR,8R,9aR,9bS)-
(3aS)-3aβ,4,5,6,6aβ,7,8,9,9aβ,9bα-Decahydro-8β-hydroxy-3,6,9-tris(methylene)azuleno[4,5-b]furan-2(3H)-one | [Molecular Formula]
C15H18O3 | [MOL File]
67667-64-5.mol | [Molecular Weight]
246.3 |
| Hazard Information | Back Directory | [Uses]
Isozaluzanin C (Dehydrozaluzanin c-derivative) is an anti-inflammatory agent that can be isolated from Saussurea lappa and has immunomodulatory effects. Isozaluzanin C improves tissue damage (lung, kidney, and liver) and excessive inflammation in mice induced by LPS (HY-D1056) or CRKP infection. Isozaluzanin C can be used in the study of bacterial infections and sepsi[1][2]. | [Definition]
ChEBI: Isozaluzanin C is a sesquiterpene lactone. | [References]
[1] Kalsi S,et al. Isodehydrocostus lactone and isozaluzanin C, two guaianolides from Saussurea lappa[J]. Phytochemistry, 1983, 22(9): 1993-1995.
[2] Zou, et al. Dehydrozaluzanin C-derivative protects septic mice by alleviating over-activated inflammatory response and promotes the phagocytosis of macrophages[J]. bioRxiv, 2023: 2023.11. 01.565192. |
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