| Identification | Back Directory | [Name]
N-[2-CARBAMOYL-5-(4-CHLORO-PHENYL)-THIOPHEN-3-YL]-SUCCINAMIC ACID | [CAS]
676995-91-8 | [Synonyms]
N-[2-CARBAMOYL-5-(4-CHLORO-PHENYL)-THIOPHEN-3-YL]-SUCCINAMIC ACID
Butanoic acid, 4-[[2-(aminocarbonyl)-5-(4-chlorophenyl)-3-thienyl]amino]-4-oxo- | [Molecular Formula]
C15H13ClN2O4S | [MDL Number]
MFCD00206493 | [MOL File]
676995-91-8.mol | [Molecular Weight]
352.79 |
| Hazard Information | Back Directory | [Uses]
FtsZ-IN-10 is a bacterial division inhibitor that interferes with the normal assembly of FtsZ. FtsZ-IN-10 specifically binds to Bacillus subtilis FtsZ monomers, thereby affecting their polymerization behavior. FtsZ-IN-10 may also activate nucleotide-free archaeal FtsZ to form ordered polymers. FtsZ-IN-10 can hinder the localization of FtsZ in the Z ring and inhibit bacterial cell division. Chlorinated analogs of FtsZ-IN-10 show the ability to inhibit the growth of antibiotic-resistant clinical isolates such as Staphylococcus aureus and Enterococci[1]. | [References]
[1] Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ DOI:10.1021/cb400208z |
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