| Identification | Back Directory | [Name]
Facinicline | [CAS]
677306-35-3 | [Synonyms]
R-3487
MEM-3454
RO-5313534
Facinicline
Facinicline (free base)
1H-Indazole-3-carboxamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl- | [Molecular Formula]
C15H18N4O | [MDL Number]
MFCD27957376 | [MOL File]
677306-35-3.mol | [Molecular Weight]
270.33 |
| Hazard Information | Back Directory | [Uses]
Facinicline (RG3487) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM[1]. | [References]
[1] Tanya L Wallace, et al. RG3487, a Novel Nicotinic α7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents. J Pharmacol Exp Ther. 2011 Jan;336(1):242-53. DOI:10.1124/jpet.110.171892 |
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