| Identification | Back Directory | [Name]
ENOXAPARIN SODIUM, EP STANDARD | [CAS]
679809-58-6 | [Synonyms]
Enoxil
Klexane
Clexane
Lovenox
Unii-8nz41mik1o
ENOXAPARIN SODIUM
Enoxaparin SodiuM EP
Lovenox (preservative free)
ENOXAPARIN SODIUM, EP STANDARD | [Molecular Formula]
C57H82N4Na4O53S3 | [MDL Number]
MFCD00081689 |
| Chemical Properties | Back Directory | [Melting point ]
>191°C (dec.) | [storage temp. ]
Room Temperature, Under inert atmosphere | [solubility ]
Water (Slightly) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Description]
Enoxaparin sodium is the sodium salt of a low-molecular-mass heparin that is obtained by alkaline depolymerisation of the benzyl ester derivative of heparin from porcine intestinal mucosa. Enoxaparin sodium is an antithrombotic agent (ATC code B01AB05) characterized by a higher ratio of antithrombotic activity to anticoagulant activity compared to unfractionated heparin.
Specifically, Enoxaparin sodium as the sodium salt of depolymerized Heparin is subject to characteristic structural modifications from the effects of the depolymerization reaction. Characteristic structures such as partial transformation of glucosamines into mannosamines, formation of 1,6-anydro derivatives and 2,3 epoxide residues with subsequent conversion to galacturonic acid and the change in the proportion of the sulfated and non-sulfated residues are some of the changes that constitute Enoxaparin a structurally difficult to characterize molecule. As such no single technique or parameter is adequate to fully characterize the Enoxaparin molecule as part of a biosimilarity exercise against the reference. | [Chemical Properties]
degree of sulphatation is ~ 2 per disaccharide | [Uses]
Enoxaparin sodium is intended for use in the treatment of deep vein thrombosis; prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, and treatment of acute deep vein thrombosis.
| [Indications]
Enoxaparin sodium is a gold standard for antithrombosis which has the largest number of indications among all LMWHs. Prophylaxis of vein thrombosis diseases (prevent intra-vein thrombosis), treatment of deep venous thrombosis, Prevention of thrombus formation in the in vitro circulation during hemodialysis, treatment of acute unstable angina and non-Q-wave myocardial infarction, administered with Aspirin. | [Brand name]
Lovenox
(Sanofi Aventis). | [Veterinary Drugs and Treatments]
Enoxaparin may be useful for prophylaxis or treatment of deep vein
thrombosis or pulmonary embolus. Recent pharmacokinetic work
in dogs and cats, raises questions whether the drug can be effectively
and practically administered long-term. In humans, it is also
indicated for prevention of ischemic complications associated with
unstable angina/non Q-wave MI. | [storage]
4°C, protect from light |
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