| Identification | More | [Name]
1-(4-BROMOPHENYL)PIPERAZINE HYDROCHLORIDE | [CAS]
68104-62-1 | [Synonyms]
1-(4-BROMOPHENYL)-PIPERAZINE HCL
1-(4-BROMOPHENYL)PIPERAZINE HYDROCHLORIDE
RARECHEM AH CK 0050
1-(4-Bromophenyl)piperazine hydrochloride 98%
1-(4-Bromophenyl)-piperazine x HCl
1-(4-Bromophenyl)piperazin HCl | [Molecular Formula]
C10H14BrClN2 | [MDL Number]
MFCD00674134 | [Molecular Weight]
277.59 | [MOL File]
68104-62-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
>280°C (dec.) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO: 10 mg/ml; PBS (pH 7.2): 10 mg/ml | [Water Solubility ]
Soluble in water | [form ]
powder to crystal | [color ]
White to Almost white | [InChI]
InChI=1S/C10H13BrN2.ClH/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13;/h1-4,12H,5-8H2;1H | [InChIKey]
YDVSFRZKQMQPJD-UHFFFAOYSA-N | [SMILES]
C1(C=CC(Br)=CC=1)N1CCNCC1.Cl | [CAS DataBase Reference]
68104-62-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [HS Code ]
2933.59.8000 |
| Hazard Information | Back Directory | [Description]
1-(4-Bromophenyl)piperazine hydrochloride is an important organic synthetic intermediate, playing a crucial role, especially in medicinal chemistry. It is not typically used as a final product, but rather introduced as a structural unit (i.e., a "building block") into more complex molecules to construct drug molecules with specific biological activities. The "p-bromophenyl" and "piperazine ring" contained in its structure are common pharmacophores in many central nervous system drugs, such as antipsychotics and antidepressants. | [Uses]
1-(4-Bromophenyl)piperazine Hydrochloride is useful in the synthesis of large bifunctional heterocycles use in targeted degradation of rapidly accelerated fibrosarcoma polypeptides | [Synthesis]
P-Bromoaniline undergoes a biphilic nucleophilic substitution reaction with bis(2-chloroethyl)amine in the presence of a base (e.g., sodium carbonate) to directly generate 1-(4-bromophenyl)piperazine. Finally, 1-(4-bromophenyl)piperazine reacts with hydrochloric acid to synthesize 1-(4-bromophenyl)piperazine hydrochloride. |
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ABINTIO BIOSCIENCES
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+91-6302904517 +91-7386106841 |
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www.abintiobiosciences.com |
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