| Identification | More | [Name]
1-(4-BROMOPHENYL)PIPERAZINE HYDROCHLORIDE | [CAS]
68104-62-1 | [Synonyms]
1-(4-BROMOPHENYL)-PIPERAZINE HCL
1-(4-BROMOPHENYL)PIPERAZINE HYDROCHLORIDE
RARECHEM AH CK 0050
1-(4-Bromophenyl)piperazine hydrochloride 98%
1-(4-Bromophenyl)-piperazine x HCl
1-(4-Bromophenyl)piperazin HCl | [Molecular Formula]
C10H14BrClN2 | [MDL Number]
MFCD00674134 | [Molecular Weight]
277.59 | [MOL File]
68104-62-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
>280°C (dec.) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO: 10 mg/ml; PBS (pH 7.2): 10 mg/ml | [Water Solubility ]
Soluble in water | [form ]
powder to crystal | [color ]
White to Almost white | [InChI]
InChI=1S/C10H13BrN2.ClH/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13;/h1-4,12H,5-8H2;1H | [InChIKey]
YDVSFRZKQMQPJD-UHFFFAOYSA-N | [SMILES]
C1(C=CC(Br)=CC=1)N1CCNCC1.Cl | [CAS DataBase Reference]
68104-62-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
1-(4-Bromophenyl)piperazine hydrochloride is an important organic synthetic intermediate, playing a crucial role, especially in medicinal chemistry. It is not typically used as a final product, but rather introduced as a structural unit (i.e., a "building block") into more complex molecules to construct drug molecules with specific biological activities. The "p-bromophenyl" and "piperazine ring" contained in its structure are common pharmacophores in many central nervous system drugs, such as antipsychotics and antidepressants. | [Uses]
1-(4-Bromophenyl)piperazine Hydrochloride is useful in the synthesis of large bifunctional heterocycles use in targeted degradation of rapidly accelerated fibrosarcoma polypeptides | [Synthesis]
P-Bromoaniline undergoes a biphilic nucleophilic substitution reaction with bis(2-chloroethyl)amine in the presence of a base (e.g., sodium carbonate) to directly generate 1-(4-bromophenyl)piperazine. Finally, 1-(4-bromophenyl)piperazine reacts with hydrochloric acid to synthesize 1-(4-bromophenyl)piperazine hydrochloride. |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Tetranov Biopharm
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| Telephone: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
| Company Name: |
T&W GROUP
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| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
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