| Identification | Back Directory | [Name]
1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione | [CAS]
6812-87-9 | [Synonyms]
NSC 122417
12-Hydroxyabieta-8,12-diene-11,14-dione
12-Hydroxy-13-isopropylpodocarpa-8,12-diene-11,14-dione
1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione
(4bS)-2-Isopropyl-3-hydroxy-4bα,8,8-trimethyl-4b,5,6,7,8,8aβ,9,10-octahydrophenanthrene-1,4-dione
(4bS,8aS)-4b,5,6,7,8,8a,9,10-Octahydro-3-hydroxy-4b,8,8-trimethyl-2-isopropyl-1,4-phenanthrenedione
(4bS,8aS)-3-hydroxy-2-isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-1,4-dione
1,4-Phenanthrenedione, 4b,5,6,7,8,8a,9,10-octahydro-3-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)- | [Molecular Formula]
C20H28O3 | [MDL Number]
MFCD26406092 | [MOL File]
6812-87-9.mol | [Molecular Weight]
316.43 |
| Chemical Properties | Back Directory | [Melting point ]
181.5-183.0 °C(Solv: acetic acid (64-19-7)) | [Boiling point ]
426.4±45.0 °C(Predicted) | [density ]
1.12±0.1 g/cm3(Predicted) | [pka]
4.50±1.00(Predicted) |
| Hazard Information | Back Directory | [Uses]
Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells[1]. | [Definition]
ChEBI: Royleanone is a diterpenoid. | [References]
[1] Wu X, et al. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23(4):1055-1060. PMID:30358211 |
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