| Identification | Back Directory | [Name]
Copper, [[2,2'-(1,2-dimethyl-1,2-ethanediylidene)bis[N-phenylhydrazinecarbothioamidato-κN2,κS]](2-)]-, (SP-4-2)- | [CAS]
68341-12-8 | [Synonyms]
CuATSP
Copper, [[2,2'-(1,2-dimethyl-1,2-ethanediylidene)bis[N-phenylhydrazinecarbothioamidato-κN2,κS]](2-)]-, (SP-4-2)- | [Molecular Formula]
C18H20CuN6S2 | [MOL File]
68341-12-8.mol | [Molecular Weight]
448.07 |
| Hazard Information | Back Directory | [Uses]
CuATSP, a potent inhibitor of ferroptotic cell death, is almost 20-fold more potent than CuATSM. | [Biological Activity]
CuATSP is a CuATSM analog with >10-fold enhanced ferropotosis inhibitory potency (CuATSP/CuATSM IC50 against 150 nM RSL3-induced ferroptosis = 8.5/160 nM using Pfa1 mouse embryonic fibroblasts,16/170 nM using HT-22 mouse hippocampal cells). CuATSP and CuATSM exert their radical-trapping antioxidant (RTA) and (phospho)lipid peroxidation inhibitory potency via an initial reversible addition of a peroxyl radical to the bis(thiosemicarbazone) ligandfollowed by a subsequent H-atom transfer (HAT) th at drives the reaction forward. | [storage]
Store at -20°C | [References]
[1] Zilka O, et al. Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death. J Am Chem Soc. 2021 Nov 17;143(45):19043-19057. DOI:10.1021/jacs.1c08254 |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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