| Identification | Back Directory | [Name]
(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6- yl]methylamino]benzoyl]amino]pentanedioic acid | [CAS]
68538-85-2 | [Synonyms]
(S)-Leucovorin
(6S)-Leucovorin
Folinic Acid EP Impurity H
(6S)-5-Formyltetrahydrofolic acid
Impurity H of Calcium Levofolinate
Folinic Acid Impurity H (Levofolinic Acid)
N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid
L-Glutamic acid, N-[4-[[[(6S)-2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-
(-)-N-[4-[[[(6S)-2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxopteridin-6β-yl]methyl]amino]benzoyl]-L-glutamic acid
(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6- yl]methylamino]benzoyl]amino]pentanedioic acid | [Molecular Formula]
C20H23N7O7 | [MDL Number]
MFCD31926945 | [MOL File]
68538-85-2.mol | [Molecular Weight]
473.44 |
| Hazard Information | Back Directory | [Uses]
Levoleucovorin (Levofolinic acid) is the pharmacologically active levoisomer of racemic leucovorin. Levoleucovorin can be used as a rescue agent after high-dose Methotrexate (HY-14519) therapy, and in combination with fluorouracil for the research of advanced metastatic colorectal cancer[1]. | [Definition]
ChEBI: The pharmacologically active (6S)-stereoisomer of 5-formyltetrahydrofolic acid. | [References]
[1] Chuang VT, et al. Levoleucovorin as replacement for leucovorin in cancer treatment. Ann Pharmacother. 2012 Oct;46(10):1349-57. DOI:10.1345/aph.1Q677 |
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