| Identification | Back Directory | [Name]
ACTH (7-38) (HUMAN) | [CAS]
68563-24-6 | [Synonyms]
acth(7-38
ACTH 1-39
CIP (HUMAN)
CORTICOTROPIN A
ACTH (7-38) (HUMAN)
ACTH (7-38) (HUMAN) USP/EP/BP
FRWGKPVGKKRRPVKVYPNGAEDESAEAFPLE
CORTICOTROPIN-INHIBITING PEPTIDE
Corticotropin-Inhibiting Peptide (CIP)
CORTICOTROPIN-INHIBITING PEPTIDE (HUMAN)
ADRENOCORTICOTROPIC HORMONE FRAGMENT 7-38
ADRENOCORTICOTROPIC HORMONE (7-38) (HUMAN)
adrenocorticotropic hormone fragment*7-38 human
ADRENOCORTICOTROPIC HORMONE HUMAN FRAGMENT 7-38
CORTICOTROPIN-LIKE INTERMEDIATE PEPTIDE HUMAN (7-38)
ACTH (7-38) (huMan)
Corticotropin-Inhibiting Peptide (CIP)
PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-GLY-ALA-GLU-ASP-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU
H-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-GLY-ALA-GLU-ASP-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-OH
PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-GLY-ALA-GLU-ASP-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU HUMAN
ACTH (7-38) (human) H-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-OH | [Molecular Formula]
C167H257N47O46 | [MDL Number]
MFCD00081282 | [Molecular Weight]
3659.11 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [form ]
Solid | [color ]
White to off-white | [Sequence]
H-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-OH |
| Hazard Information | Back Directory | [Uses]
Adrenocorticotropic hormone fragment 7-38 human has been used as astandard in external calibration for mass spectrometry. | [Biological Activity]
Adrenocorticotropic hormone (ACTH) is a polypeptide hormone thatstimulates adrenocortical activity. It is produced by the prohormoneproopiomelanocortin (POMC)which is synthesized in the corticotroph andmelanotroph cells found in the intermediate and anterior lobe of the pituitarygland and the arcuate nucleus of the hypothalamus. ACTH is also synthesized inthe skin. It plays a role in controlling steroidogenesis in the adrenal glandand prevents reactive oxygen species (ROS)-induced cell toxicity. Higher levelsof ACTH lead to skin hyperpigmentation due to the hyperstimulation ofmelanocytescharacteristic of primary adrenal insufficiency (PAI). Deficiencyof ACTH synthesisreceptorsor signaling is associated with adrenalinsufficiency. |
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Sigma-Aldrich
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