| Identification | Back Directory | [Name]
5-{[2-(6-AMINO-9H-PURIN-9-YL)ETHYL]AMINO}-1-PENTANOL | [CAS]
686301-48-4 | [Synonyms]
NB001
HTS 09836
5-{[2-(6-AMINO-9H-PURIN-9-YL)ETHYL]AMINO}-1-PENTANO
5-{[2-(6-AMINO-9H-PURIN-9-YL)ETHYL]AMINO}-1-PENTANOL | [Molecular Formula]
C12H20N6O | [MDL Number]
MFCD03086724 | [MOL File]
686301-48-4.mol | [Molecular Weight]
264.327 |
| Chemical Properties | Back Directory | [Appearance]
Off-White to Pale Pink Solid | [Melting point ]
146-148°C | [Boiling point ]
521.3±60.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
-20?C Freezer | [solubility ]
H2O: ≥24mg/mL | [form ]
powder | [pka]
15.17±0.10(Predicted) | [color ]
white to tan | [Water Solubility ]
H2O: ≥24mg/mL |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Pale Pink Solid | [Uses]
Used for treatment of metabolic disorders such as: overweight, obesity, atherosclerosis, hypertension | [Biochem/physiol Actions]
NB001, originally believed to be a selective inhibitor of adenylyl cyclase 1 (AC1), new evidence suggests NB001 does not interact with AC1 directly. NB001 may reduce cAMP accumulation in cells through an unknown mechanism that is dependent on AC1. | [in vivo]
Peturadol (20-40 mg/kg, po, single dose) exhibits analgesic effect, reduces anxiety related behavior in MPTP (HY-15608)-induced Parkinson’s disease models[2]. | Animal Model: | MPTP (HY-15608)-induced mouse Parkinson’s disease models[2] | | Dosage: | 20-40 mg/kg | | Administration: | po, single dose | | Result: | Reduced pain-related and anxiety-related behaviors. |
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