| Identification | Back Directory | [Name]
CP 945598 hydrochloride | [CAS]
686347-12-6 | [Synonyms]
CP 945
CS-580
CP 945598-01
CP 945598 HCl
Otenabant HCl
CP-945598; CP 945598
CP-945598 HCl, >=99%
CP 945598 hydrochloride
Otenabant (Hydrochloride)
Otenabant (CP-945598) HCl
CP 945598 HCl (Otenabant HCl)
OTENABANT; CP945598; CP 945598
Otenabant (CP-945598) hydrochloride
hydrochloride Otenabant (CP-945598) HCl
1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]-4-(ethylamino)piperidine-4-carboxamide
1-(8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl)-4-(ethylamino)piperidine-4-carboxamide
1-[8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)piperidine-4-carboxamide hydrochloride
1-[8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylaMino)-4-piperidinecarboxaMide Hydrochloride
1-[8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-
4-(ethylaMino)-4-piperidinecarboxaMide Monohydrochloride
1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride
4-PiperidinecarboxaMide, 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylaMino)-, (Hydrochloride) (1:1) | [Molecular Formula]
C25H26Cl3N7O | [MDL Number]
MFCD18251544 | [MOL File]
686347-12-6.mol | [Molecular Weight]
546.879 |
| Chemical Properties | Back Directory | [Melting point ]
275-276℃ (decomposition) | [storage temp. ]
room temp | [solubility ]
DMSO: soluble1mg/mL, clear (warmed) | [form ]
powder | [color ]
white to beige |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
CP 945598 is a selective, high affinity CB1 antagonist (Ki values are 0.7 and 0.12 nM in binding and functional assays respectively). Displays low affinity for CB2 receptors (Ki = 7600 nM). | [Biological Activity]
CP-945,598 is a potentselectivehigh affinity and competitive cannabinoid type 1 (CB1) receptor antagonist. CP-945,598 inhibits both basal and cannabinoid agonist-mediated CB1 receptor signaling in vitro and in vivo. CP-945,598 exhibits anorectic activity in two models of acute food intake in rodentsfast-induced re-feeding and spontaneousnocturnal feeding.''CP-945,598 is also known as 1-(8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl)-4-(ethylamino)piperidine-4-carboxamide. This orally active antagonist of the cannabinoid CB-1 receptor may be used in the treatment of obesity. | [in vivo]
Otenabant acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation. Otenabant (10 mg/kg, p.o.) promotes a 9%, vehicle adjusted weight loss in a 10 day weight loss study in diet-induced obese mice[1]. Otenabant HCl reverses four cannabinoid agonistmediated behaviors (locomotor activity, hypothermia, analgesia, and catalepsy) following administration of the synthetic CB1 receptor agonist CP-55940. Otenabant HCl exhibits dose-dependent anorectic activity in a model of acute food intake in rodents and increased energy expenditure and fat oxidation[2]. | [storage]
Store at -20°C |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
LETOPHARM LIMITED
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| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
D&C Chemicals
|
| Telephone: |
+86-21-58447131 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
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| Website: |
www.spiropharma.com.cn |
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