ChemicalBook--->CAS DataBase List--->912444-00-9

912444-00-9

912444-00-9 Structure

912444-00-9 Structure
IdentificationMore
[Name]

Veliparib (ABT-888)
[CAS]

912444-00-9
[Synonyms]

A861695
Veliparib
NSC 737664
ABT-888 2HCl
ABT-888,Veliparib
Veliparib(chiral)
ABT-888 (Veliparib, NSC 737664)
(S)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide
2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide
2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide
1H-Benzimidazole-4-carboxamide, 2-((2R)-2-methyl-2-pyrrolidinyl)-
(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]iMidazole-4-carboxaMide
(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide (VELIPARIB)
Veliparib 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide
2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide Veliparib (ABT-888)
2-[(R)-2-Methylpyrrolidin-2-yl]-1H-benziMidazole-4-carboxaMide 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benziMidazole-4-carboxaMide
[EINECS(EC#)]

681-636-1
[Molecular Formula]

C13H16N4O.2ClH
[MDL Number]

MFCD16661059
[MOL File]

912444-00-9.mol
[Molecular Weight]

317.218
Chemical PropertiesBack Directory
[Boiling point ]

579.0±40.0 °C(Predicted)
[density ]

1.274
[storage temp. ]

Store at -20°C
[solubility ]

insoluble in H2O; ≥10.6 mg/mL in EtOH with ultrasonic; ≥6.11 mg/mL in DMSO
[form ]

solid
[pka]

9.22±0.30(Predicted)
[CAS DataBase Reference]

912444-00-9
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Usage]

ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo.
[Uses]

ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo.
[Definition]

ChEBI: A benzimidazole substituted with a carbamoyl group at C-4 and a (2R)-2-methylpyrrolidin-2-yl moiety at C-2. It is a potent, orally bioavailable PARP inhibitor.
[storage]

Store at -20°C
Questions And AnswerBack Directory
[Abstract]

Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments.
Veliparib (ABT-888) is being investigated to treat squamous and non-squamous non-small cell lung cancer, BRCA breast cancer, triple negative breast cancer and ovarian cancer.
[Biological activity]

Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
[In vitro]

Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor,which inhibits PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays,respectively.ABT-888 reduces clonogenic survival and inhibits DNA repair in H460 cells. ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells.
[In vivo]

ABT-888 inhibits PARP in B16F10 and 9L xenograft models, thus enhancing the anticancer activity of temozolomide. The Combined with other cytotoxic agents, ABT-888 shows strong antitumor effect in MX-1 xenograft model. ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg according to the the size of tumors in A375 and Colo829 xenograft models.
[Features]

ABT-888 enhances the effectiveness of common cancer treatments, such as radiation therapy and alkylating agents.
[References]

https://www.abbvie.com/our-science/pipeline/veliparib.html
https://en.wikipedia.org/wiki/Veliparib
Spectrum DetailBack Directory
[Spectrum Detail]

Veliparib(912444-00-9)1HNMR
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