| Identification | Back Directory | [Name]
(+/-)-8-PRENYLNARINGENIN | [CAS]
68682-02-0 | [Synonyms]
rac 8-Prenylnaringenin
(+/-)-8-PRENYLNARINGENIN
Naringenin 8-Prenyl Racemate
2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-Methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
(±)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-Methyl-2-butenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)- | [EINECS(EC#)]
245-096-7 | [Molecular Formula]
C20H20O5 | [MDL Number]
MFCD21364781 | [MOL File]
68682-02-0.mol | [Molecular Weight]
340.37 |
| Chemical Properties | Back Directory | [Melting point ]
183-184 °C | [Boiling point ]
597.6±50.0 °C(Predicted) | [density ]
1.314±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Light yellow powder | [pka]
7.70±0.40(Predicted) | [color ]
Off-White to Pale Yellow | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Description]
(±)-8-Prenylnaringenin ((±)-8-PN) is a prenylflavonoid with potent estrogenic activity that can be isolated from hops. It inhibits both isoforms of the human estrogen receptor (ER; IC50s = 57 and 68 nM for ERα and ERβ, respectively). (±)-8-PN is effective in vivo, suppressing loss of bone mineral density in ovariectomized rats and blocking changes in tail skin temperature in a rat model of postmenopausal hot flashes. | [Uses]
8-Prenylnaringenin is a prenylflavonoid, a class on non-steroidal phytoestrogen that mimicks and/or modulating endogenous estrogens via estrogen receptor binding. | [Definition]
ChEBI: Rac 8-Prenylnaringenin is a member of flavanones. | [in vivo]
(±)-8-Prenylnaringenin (50 mg/kg; orally gavage; once daily; for 12 days) ameliorates impaired glucose homeostasis and islet dysfunction induced by STZ treatment. (±)-8-Prenylnaringenin increases the protein expression levels of ERα in the pancreas and liver and of fibroblast growth factor 21 in the liver[3]. | Animal Model: | Male C57BL/6J mice (Seven-week-old) injected with Streptozotocin (STZ)[3] | | Dosage: | 50 mg/kg | | Administration: | Orally gavage; once daily; for 12 days | | Result: | Ameliorated impaired glucose homeostasis and islet dysfunction induced by STZ treatment. |
| [IC 50]
ERα: 57 nM (IC50); ERβ: 68 nM (IC50) |
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| Company Name: |
BOC Sciences
|
| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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