| Identification | Back Directory | [Name]
Kurarinol | [CAS]
855746-98-4 | [Synonyms]
4'',5''-Dihydro-5''-hydroxysophoraflavanone G 5-methyl ether
2-(2,4-dihydroxy-phenyl)-7-hydroxy-8-[2-(3-hydroxy-3-methyl-butyl)-3-methyl-but-3-enyl]-5-methoxy-chroman-4-one
(2S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2S)- | [Molecular Formula]
C26H32O7 | [MDL Number]
MFCD11840665 | [MOL File]
855746-98-4.mol | [Molecular Weight]
456.53 |
| Chemical Properties | Back Directory | [Melting point ]
166-169 °C | [Boiling point ]
683.8±55.0 °C(Predicted) | [density ]
1.250±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
7.54±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase[1]. | [Definition]
ChEBI: A trihydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 7, 2' and 4' , a methoxy group at position 5 and a (2S)-5-hydroxy-5-methyl-2-(prop-1-en-2-yl)hexyl group at position 8 respectively. | [in vivo]
Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduces serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats[3].
| Animal Model: | Male Sprague-Dawley rats (120-130g), hypercholesterolemic models[3] | | Dosage: | 20 mg/kg | | Administration: | Oral administration, daily, for 3 days | | Result: | Decreased serum TC, TG, and LDL-C levels. |
| [target]
STAT | HBV | Tyrosinase | [References]
[1] Y B Ryu, et al. Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens. Phytomedicine. 2008 Aug;15(8):612-8. DOI:10.1016/j.phymed.2007.09.022
[2] Guangwen Shu, et al. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicol Appl Pharmacol. 2014 Dec 1;281(2):157-65. DOI:10.1016/j.taap.2014.06.021
[3] Hyun Young Kim, et al. Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Biol Pharm Bull. 2008 Jan;31(1):73-8. DOI:10.1248/bpb.31.73 |
|
|