| Identification | Back Directory | [Name]
asimilobine | [CAS]
6871-21-2 | [Synonyms]
asimilobine
R-(-)-asimilobine
1-Methoxy-6abeta-noraporphin-2-ol
(R)-5,6,6a,7-Tetrahydro-1-methoxy-4H-dibenzo[de,g]quinolin-2-ol
4H-Dibenzo[de,g]quinolin-2-ol, 5,6,6a,7-tetrahydro-1-methoxy-, (6aR)- | [Molecular Formula]
C17H17NO2 | [MDL Number]
MFCD28385980 | [MOL File]
6871-21-2.mol | [Molecular Weight]
267.32 |
| Chemical Properties | Back Directory | [Melting point ]
177-179℃ (acetone ) | [InChI]
InChI=1S/C17H17NO2/c1-20-17-14(19)9-11-6-7-18-13-8-10-4-2-3-5-12(10)16(17)15(11)13/h2-5,9,13,18-19H,6-8H2,1H3/t13-/m1/s1 | [InChIKey]
NBDNEUOVIJYCGZ-CYBMUJFWSA-N | [SMILES]
N1[C@@]2([H])C3=C(C(OC)=C(O)C=C3CC1)C1=CC=CC=C1C2 |
| Hazard Information | Back Directory | [Uses]
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity[1][2]. | [Definition]
ChEBI: A natural product found in Annona glabra. | [IC 50]
Plasmodium; Dopamine Receptor; serotonergic receptor | [References]
[1] N Shoji, et al. Asimilobine and Lirinidine, Serotonergic Receptor Antagonists, From Nelumbo Nucifera. J Nat Prod. Jul-Aug 1987;50(4):773-4. DOI:10.1021/np50052a044
[2] Chun-Mei Jin, et al. Effects of Asimilobine on Dopamine Biosynthesis and l-DOPA-induced Cytotoxicity in PC12 Cells. J Asian Nat Prod Res. Jul-Aug 2008;10(7-8):747-55. DOI:10.1080/10286020802030892 |
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