| Identification | Back Directory | [Name]
2-(4-methoxyphenyl)-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide | [CAS]
692869-38-8 | [Synonyms]
WAY-624704
ROCK1-IN-1
2-(4-Methoxyphenyl)-N-(4-(pyridin-4-yl)thiazol-2-yl)acetamide
2-(4-methoxyphenyl)-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide | [Molecular Formula]
C17H15N3O2S | [MOL File]
692869-38-8.mol | [Molecular Weight]
325.38 |
| Chemical Properties | Back Directory | [density ]
1.309±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture | [solubility ]
DMSO : 125 mg/mL (384.17 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
8.80±0.50(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
ROCK1-IN-1 is a ROCK1 inhibitor with a Ki value of 540 nM. ROCK1-IN-1 can be used for the research of hypertension, glaucoma and erectile dysfunction[1]. | [storage]
4°C, away from moisture | [References]
[1] Green J, et al. Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors. J Med Chem. 2015 Jun 25;58(12):5028-37. DOI:10.1021/acs.jmedchem.5b00424 |
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