| Identification | Back Directory | [Name]
N-TRICOSANOYLTRYPTAMINE | [CAS]
697226-52-1 | [Synonyms]
TAT
MEC17
TAT-amide
ATAT1 human
N-TRICOSANOYLTRYPTAMINE
Tyrosine aminotransferase
TRICOSANOIC ACID TRYPTAMIDE
alpha tubulin acetyltransferase 1
N-[2-(3-INDOLYL)ETHYL]TRICOSANAMIDE
L-tyrosine:2-oxoglutarate aminotransferase
ANTI-TAT (CENTER) antibody produced in rabbit
TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-NH2
H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2 | [Molecular Formula]
C64H119N33O13 | [MDL Number]
MFCD07366643 | [MOL File]
697226-52-1.mol | [Molecular Weight]
1558.84 |
| Chemical Properties | Back Directory | [Melting point ]
116-120 °C
| [density ]
1.54±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
Solid | [color ]
White to off-white | [biological source]
rabbit | [Sequence]
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2 |
| Hazard Information | Back Directory | [Uses]
TAT-amide is a cell penetrating peptide. Cell-penetrating peptides (CPPs) are short amino acid sequences able to enter different cells[1][2]. | [Biological Activity]
ATAT1 (α tubulin acetyltransferase 1) catalyses the acetylation of lysine 40 of α-tubulin and microtubule. ATAT1 expression is essential for microtubule stabilization and mediates cilium formation. Upart from acetylationαTAT1 interacts with doublecortin (a microtubule associated protein) to degrade microtubules th at are not aligned with acetyltransferase activity. αTAT1 regulates the Wnt1 signalling pathway via β-catenin and promotes tumorigenesis. Overexpression of the ATAT1 gene is observed in colon cancer and is known to contribute to its progression. | [References]
[1] Xu P, et al. Precise control of apoptosis via gold nanostars for dose dependent photothermal therapy of melanoma. J Mater Chem B. 2019 Nov 28;7(44):6934-6944. DOI:10.1039/c9tb01956a
[2] Okuda-Shinagawa NM, et al. Fluorescent and Photosensitizing Conjugates of Cell-Penetrating Peptide TAT(47-57): Design, Microwave-Assisted Synthesis at 60 °C, and Properties. ACS Omega. 2017 Nov 30;2(11):8156-8166. DOI:10.1021/acsomega.7b01127 |
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| Company Name: |
Ontores Biotech
|
| Telephone: |
0571-88760729 18072970094 |
| Website: |
www.ontoresinc.cn |
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