| Identification | Back Directory | [Name]
dido | [CAS]
69839-83-4 | [Synonyms]
dido
Didox
NSC-324360
Didox, NSC-324360
Didox Exclusive
4-Trihydroxybenzamide
N,3,4-trihydroxybenzamide
Benzamide, N,3,4-trihydroxy-
3,4-dihydroxybenzohydroxamic acid | [Molecular Formula]
C7H7NO4 | [MDL Number]
MFCD01667810 | [MOL File]
69839-83-4.mol | [Molecular Weight]
169.13 |
| Chemical Properties | Back Directory | [Melting point ]
207 °C | [density ]
1.571±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO:60.0(Max Conc. mg/mL);354.76(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);118.25(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);118.25(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);59.13(Max Conc. mM) | [form ]
A crystalline solid | [pka]
8.16±0.20(Predicted) | [color ]
Light yellow to khaki | [InChI]
InChI=1S/C7H7NO4/c9-5-2-1-4(3-6(5)10)7(11)8-12/h1-3,9-10,12H,(H,8,11) | [InChIKey]
QJMCKEPOKRERLN-UHFFFAOYSA-N | [SMILES]
C(NO)(=O)C1=CC=C(O)C(O)=C1 |
| Hazard Information | Back Directory | [Description]
Polyhydroxylated aromatic compounds, both natural and synthetic, are important biological antioxidants. Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients with dementia. It also increases the radiosensitivity of cancer cells by inhibition of ribonucleotide reductase, resulting in a reduction of bcl-2 mediated resistance to apoptosis. | [Uses]
Didox is a synthetic antioxidant that reduces oxidative injury levels. | [Definition]
ChEBI: N-3,4-tridhydroxybenzamide is a member of benzoic acids. | [in vivo]
Once engraftment is established by bioluminescent imaging, the animals receive daily administrations of Didox at 425 mg/kg via IP injection over 5 days. Didox (NSC-324360) treatment significantly reduces leukemic burden compared to vehicle treated controls (p=0.0026 and p=0.0342). More importantly, Didox (NSC-324360) provides a significant survival benefit (p<0.0001 and p=0.0094)[2]. | [storage]
Store at -20°C | [References]
[1] J TURCHAN. Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants.[J]. Neurology, 2003, 60 2: 307-314. DOI: 10.1212/01.wnl.0000042048.85204.3d
[2] MOHAMMED S INAYAT. Didox (a novel ribonucleotide reductase inhibitor) overcomes Bcl-2 mediated radiation resistance in prostate cancer cell line PC-3.[J]. Cancer Biology & Therapy, 2002, 1 5: 539-545. DOI: 10.4161/cbt.1.5.174 |
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| Company Name: |
D&C Chemicals
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| Telephone: |
+86-21-58447131 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
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