| Identification | Back Directory | [Name]
NSC 46633 | [CAS]
699-91-2 | [Synonyms]
NSC 46633
2-Acetyl-6-methylphenol
2'-Hydroxy-3'-methylacetophenone
1-(2-Hydroxy-3-methylphenyl)ethanone
Ethanone, 1-(2-hydroxy-3-Methylphenyl)-
1-(2-hydroxy-3-Methylphenyl)ethan-1-one
1-(2-Hydroxy-3-methylphenyl)ethan-1-one, 2-Acetyl-6-methylphenol, 3-Acetyl-2-hydroxytoluene | [Molecular Formula]
C9H10O2 | [MDL Number]
MFCD07425673 | [MOL File]
699-91-2.mol | [Molecular Weight]
150.17 |
| Chemical Properties | Back Directory | [Boiling point ]
238℃ | [density ]
1.106 | [Fp ]
97℃ | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
10.51±0.10(Predicted) | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Uses]
2-Acetyl-6-methylphenol is used to prepare (hydroxyphenyl)(piperidinyl)pyridines as IκB kinase β inhibitors and orally active anti-inflammatory agents. | [Preparation]
Preparation by reaction of acetic acid on o-cresol with zinc chloride at reflux (Nencki reaction) (20%). | [References]
[1] Patent: US2014/349990, 2014, A1. Location in patent: Paragraph 0739; 0740
[2] Patent: WO2014/191896, 2014, A1. Location in patent: Page/Page column 147
[3] Organic and Biomolecular Chemistry, 2015, vol. 13, # 36, p. 9418 - 9426
[4] Patent: WO2014/191894, 2014, A1. Location in patent: Page/Page column 104; 105 |
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