| Identification | Back Directory | [Name]
NSC 38280 | [CAS]
70-09-7 | [Synonyms]
Wander
Hr 2198
Nsc 60339
NSC 38280
2-Chloro-4',4''-di-2-imidazolin-2-yl-terephthalanilide
2-Chloro-N,N'-bis[4-(2-imidazolin-2-yl)phenyl]terephthalamide
Terephthalanilide, 2-chloro-4',4''-di-2-imidazolin-2-yl- (8ci)
1,4-Benzenedicarboxamide, 2-chloro-N,N'-bis(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)- (9ci) | [MOL File]
70-09-7.mol |
| Hazard Information | Back Directory | [Uses]
NSC-60339, an efflux pump inhibitor and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent[1][2]. | [storage]
Store at -20°C | [References]
[1] D. W. Yesair, et al. Relationship of Phthalanilide-Lipid Complexes to Uptake and Retention of 2-Chloro-4′,4″-di(2-imidazolin-2-yl)terephthalanilide (NSC 60339) by Sensitive and Resistant P388 Leukemia Cells. CANCER RESEARCH 26 Part 1: 202-207, February 19
[2] Yesair DW, et al. The retention or efflux of phthalanilide (NSC 60339)-lipid complexes by sensitive or resistant murine tumor cells and Escherichia coli B. Cancer Res. 1968 Feb;28(2):314-9. PMID:4868016
[3] Haynes KM, et al. Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli. J Med Chem. 2017 Jul 27;60(14):6205-6219. DOI:10.1021/acs.jmedchem.7b00453
[4] Abdali N, et al. Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump. ACS Infect Dis. 2017 Jan 13;3(1):89-98. DOI:10.1021/acsinfecdis.6b00167 |
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cjbscvictory
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https://www.weikeqi-biotech.com/ |
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