| Identification | Back Directory | [Name]
EC 1.4.3.14 | [CAS]
70132-14-8 | [Synonyms]
EC 1.4.3.14
LYSINE OXIDASE
Lysine oxidase（LO）
lysine oxidase from trichoderma viride
Native Trichoderma viride Lysine Oxidase
L-LYSINE: OXYGEN OXIDOREDUCTASE [DEAMINATING] | [MDL Number]
MFCD00131554 |
| Hazard Information | Back Directory | [Uses]
Lysine Oxidase from Trichoderma viride has been used in the preparation of luminescent biochip preparation. | [General Description]
Lysine Oxidase from Trichoderma viride is a homodimeric flavoenzyme corresponding to molecular mass of 112 kDa. It is stable at 65°C and is highly specific for L-lysine substrate. It comprises FAD-binding, substrate binding and a helical domain with distinct active site funnel. | [Biochem/physiol Actions]
Lysine Oxidase from Trichoderma viride catalyzes the formation of α-keto- ε-aminocaproate by the oxidative deamination of L-lysine. It displays anti-tumor functionality in cancer leukaemic cells. It is a tumor suppressor for squamous cell, fibroblast, ovarian and gastric tumors. Lysine oxidase also plays key role in connective tissue structural integrity and embryo development. | [in vivo]
L-Lysine α-oxidase (150 U/kg on day 2 and 75 U/kg on days 4, 6, 8, and 10; i.p.) shows anticancer activity in human tumor models[2]. | Animal Model: | 6-9 weeks, Female Balb/c nude mice (SKBR3, HCT116, Bro, SKOV3, Alex, T47D, LS174T tumor models)[2] | | Dosage: | 150 U/kg on day 2 and 75 U/kg on days 4, 6, 8, and 10 | | Administration: | I.p.; 10 U/ml saline solution | | Result: | Caused inhibition of tumor growth with maximal T/C of 49, 12, 51, 35, 54,36, 37% for SKBR3, HCT116, Bro, SKOV3, Alex, T47D, LS174T tumor models, respectively. |
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Creative Enzymes
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SIGMA-RBI
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