| Identification | Back Directory | [Name]
SH-5 | [CAS]
701976-54-7 | [Synonyms]
SH-5
PIA 5
AKT INHIBITOR II
D-3-DEOXY-2-O-METHYL-MYO-INOSITOL 1-[(R)-2-METHOXY-3-(OCTADECYLOXY)PROPYL HYDROGEN PHOSPHATE]
1-Deoxy-6-O-methyl-L-chiro-inositol 5-[(2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
L-chiro-Inositol, 1-deoxy-6-O-methyl-, 5-[(2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
SH5 PIA5. LchiroInositol 1deoxy6Omethyl 5(2R)2methoxy3(octadecyloxy)propyl hydrogen phosphate. Akt inhibitor II | [Molecular Formula]
C29H59O10P | [MDL Number]
MFCD08703608 | [MOL File]
701976-54-7.mol | [Molecular Weight]
598.75 |
| Hazard Information | Back Directory | [Uses]
SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke[1]. | [Biological Activity]
Cell permeable: yes''Primary Target
Akt''Product does not compete with ATP.''Reversible: yes | [Enzyme inhibitor]
This phosphatidylinositol analogue (FWfree-acid = 598.76 g/mol), also known as SH-5, inhibits the proto-oncogenic serine/threonine kinase Akt (protein kinase B), inducing apoptosis. Specific inhibition of Akt by these compounds validates ligand design targeted to the PH domains of crucial signaling proteins, thus providing a unique class of possible cancer therapeutics. | [References]
[1] Sethi G, et al. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochem Pharmacol. 2008 Dec 1;76(11):1404-16. DOI:10.1016/j.bcp.2008.05.023 |
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