| Identification | Back Directory | [Name]
SH-6 | [CAS]
701976-55-8 | [Synonyms]
SH-6
PIA 6
AKT INHIBITOR III
SH 6 (enzyme inhibitor)
D-2,3-DIDEOXY-MYO-INOSITOL 1-[(R)-2-METHOXY-3-(OCTADECYLOXY)PROPYL HYDROGEN PHOSPHATE]
D-2,3-Dideoxy-2-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
Phosphoric acid, mono[(2R)-2-methoxy-3-(octadecyloxy)propyl] mono[(1R,2R,3S,4R)-2,3,4-trihydroxycyclohexyl] ester | [Molecular Formula]
C28H57O9P | [MDL Number]
MFCD06412428 | [MOL File]
701976-55-8.mol | [Molecular Weight]
568.72 |
| Hazard Information | Back Directory | [Uses]
A cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.
A phosphatidylinositol analog that inhibits the activation of Akt and selected downstream substrates without affecting the phosphorylation of PDK-1 and other downstream kinases. Decreases phosphorylation of Akt without affecting the total Akt level. Reported to be a potent inducer of apoptosis and to selectively kill a variety of cancer cell lines expressing high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity. | [Biological Activity]
Cell permeable: yes', 'Primary Target
Akt', 'Product does not compete with ATP.', 'Reversible: yes |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Carbosynth
|
| Tel: |
+86 512 6260 5585 |
| Website: |
www.carbosynth.com |
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