70260-16-1

71637-34-8

70260-16-1

General procedure for the synthesis of (2-bromo-3-thiophene) methanol from 3-thiophene methanol: 3-hydroxymethylthiophene (12, 4.06 g, 35.6 mmol) was dissolved in 18 mL of acetic acid at room temperature, followed by the addition of N-bromosuccinimide (6.34 g, 35.6 mmol), and the reaction was stirred for 45 min. After completion of the reaction, the reaction was quenched with 1 mL of water and the mixture was poured into 250 mL of ether and washed sequentially with 100 mL of water and 100 mL of 10% aqueous NaHCO3. The organic layer was separated, dried with anhydrous Na2SO4 and the solvent was concentrated. Finally, 6.25 g of crude product 13 was obtained in 91% yield, which was directly used in the next reaction without further purification.