| Identification | Back Directory | [Name]
STING agonist-1 | [CAS]
702662-50-8 | [Synonyms]
STING agonist-1
STING agonist-1 (G10)
4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide
2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo- | [Molecular Formula]
C21H16ClFN2O3S | [MOL File]
702662-50-8.mol | [Molecular Weight]
430.88 |
| Chemical Properties | Back Directory | [Boiling point ]
668.3±55.0 °C(Predicted) | [density ]
1.428±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 0.5 mg/ml | [form ]
A crystalline solid | [pka]
13.53±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
G10 is an indirect activator of stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING. | [Uses]
G10 is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV). | [storage]
Store at -20°C | [References]
[1] TINA M. SALI. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses[J]. PLoS Pathogens, 2015, 11 1. DOI: 10.1371/journal.ppat.1005324 |
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