| Identification | Back Directory | [Name]
TSI-01 | [CAS]
704878-75-1 | [Synonyms]
TSI-01
isopropyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate
Benzoic acid, 4-(3,4-dichloro-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1-methylethyl ester | [Molecular Formula]
C14H11Cl2NO4 | [MDL Number]
MFCD03619307 | [MOL File]
704878-75-1.mol | [Molecular Weight]
328.15 |
| Chemical Properties | Back Directory | [Melting point ]
150-152°C | [storage temp. ]
Amber Vial, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Ethyl Acetate (Slightly) | [form ]
Solid | [color ]
Light Yellow |
| Hazard Information | Back Directory | [Description]
Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 μM for human LPCAT2 and LPCAT1, respectively). At 60 μM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore. | [Uses]
TSI-01 is a selectve inhibitor of LPCAT2, a platelet-activiating factor acetyltransferase (PAFAT) which acts as a pro-inflammatory phospholipid mediator. Inhibition leads to suppression of PAF biosynthesis. | [References]
[1] MEGUMI TARUI. Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2.[J]. Journal of Lipid Research, 2014, 55 7: 1386-1396. DOI: 10.1194/jlr.m049205 |
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