| Identification | Back Directory | [Name]
N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride | [CAS]
70775-75-6 | [Synonyms]
SOT360
Octenidine DiHCl
Otinidine hydrochloride
Octenidine hydrochloride
ocenidine dihydrochloride
OCTENIDINE DIHYDROCHLORIDE
TRANS-2-NONENAL 18829-56-6
Ortinidine dihydrochloride
OctenidineDihydrochloride>
Octenidine dihydrochloride 97%
Octenidine Dihydrochloride,98%
Octenidine dihydrochloride USP/EP/BP
Octenidine Dihydrochloride
DISCONTINUED, offer O239150
N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylam...
1,1'-(Decane-1,10-diyl)bis(N-octylpyridin-4(1H)-imine) dihydrochloride
-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride
N-octyl-1-[10-[4-(octylamino)pyridin-1-ium-1-yl]decyl]pyridin-1-ium-4-amine
N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylaMMoniuM) dichloride
N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride
N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-1-octanaMine Hydrochloride
Pharmaceutical Intermediate Octenidine HCl/Octenidine Hydrochloride CAS 70775-75-6
N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis(1-octanamine) dihydrochloride
1-OctanaMine,N,N'-(1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-, hydrochloride (1:2)
N,N'-(1,1'-(decane-1,10-diyl)bis(pyridin-1(1H)-yl-4(1H)-ylidene))bis(octan-1-amine) dihydrochloride
TIANFUCHEM--70775-75-6--High purity N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride factory price
Octenidine dihydrochlorideQ: What is
Octenidine dihydrochloride Q: What is the CAS Number of
Octenidine dihydrochloride Q: What is the storage condition of
Octenidine dihydrochloride | [EINECS(EC#)]
274-861-8 | [Molecular Formula]
C36H64Cl2N4 | [MDL Number]
MFCD01938808 | [MOL File]
70775-75-6.mol | [Molecular Weight]
623.826 |
| Chemical Properties | Back Directory | [Melting point ]
215-217℃ | [density ]
1.046[at 20℃] | [vapor pressure ]
0Pa at 25℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Soluble in dimethyl sulfoxide and methanol. | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
14.2g/L at 20℃ | [Merck ]
14,6754 | [Stability:]
Hygroscopic | [Cosmetics Ingredients Functions]
ANTIMICROBIAL | [InChIKey]
SMGTYJPMKXNQFY-UHFFFAOYSA-N | [SMILES]
[N+]1(CCCCCCCCCC[N+]2C=CC(NCCCCCCCC)=CC=2)=CC=C(NCCCCCCCC)C=C1.[Cl-].[Cl-] | [LogP]
1.5 at 23℃ |
| Hazard Information | Back Directory | [Description]
The antiseptic agent octenidine dihydrochloride (OCT) was developed by Sterling Winthrop (WIN41464-2) in the 1980s as an alternative to the anti-plaque agent CHX and successfully tested in vitro and in vivo. OCT has a broad spectrum of activity with similar effectiveness against Gram-negative and Gram-positive bacteria, fungi, and yeasts. Moreover, it has been shown that it may effectively interfere with the co-aggregation of dental plaque microbial colonizers without disturbing the normal, healthy oral flora. In a standardized comparison of antimicrobial activity ofthe antiseptic agents triclosan, polyvinylpyrrolidone-iodine, OCT, polyhexamethylene biguanide, and Chlorhexidine digluconat (CHX) using the min-imal effective concentration and minimum bactericidal con-centration, OCT was the most effective active agent of alltested antimicrobial substances. In other studies, the antibacterial and antiplaque efficacy of OCT was equal to or even greater than that of CHX[1].
| [Uses]
Octenidine is an antiseptic (topical). Octenidine is a cationic surfactant and bis-(dihydropyridinyl)-decane derivative. | [Application]
Octenidine dihydrochloride is a cationic antiseptic that belongs to the bispyridine class of chemicals. Its action is binding to anionic structures of the cell membrane, further bursting the membrane. It has activity against Gram-positive and Gram-negative bacteria. It was effective in oral hygiene, preventing plaque and gingivitis, as a whole body wash for methicillin-resistant S. aureus decolonization and skin disinfection of premature newborn infants. Octenidine concentrations of less than 1.5 μM (0.94 μg/mL) reduced each microbial population by more than 99% within 15 minutes. Staphylococcus epidermidis was the most susceptible of the test organisms, and E. coli and Candida albicans were the least susceptible. Octenidine was more active than chlorhexidine against each test strain. This antiseptic has not been established in veterinary medicine for skin preparation but is used for wound cleansing. | [Flammability and Explosibility]
Notclassified | [Synthesis]
The general procedure for the synthesis of N,N'-[1,10-decanediylidene-1(4H)-pyridin-4-ylidene]bis(1-octylamine) dihydrochloride from 1,10-dichlorodecane and 4-(octylamino)pyridine was as follows: 6.18 g of 4-(octylamino)pyridine base and 3.15 g of 1,10-dichlorodecane were mixed and slowly heated to 120 °C, and the reaction was exothermic to 180 °C, during which the reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, 25 mL of dimethylformamide (DMF) was added and heated to completely dissolve the mixture. Subsequently, the mixture was cooled to 0 °C to promote crystal precipitation, the crystals were collected by filtration and dried at 60 °C under reduced pressure. By the above steps, 7.3 g of N,N'-[1,10-decylidenebis-1(4H)-pyridin-4-ylidene]bis(1-octylamine) dihydrochloride was obtained in a yield of 39.0% with a melting point of 215 to 217 °C. | [in vivo]
The antimicrobial activity of octenidine hydrochloride (OCT) is maintained when applied to the skin of the hands and feet of cynomolgus monkeys. Aqueous octenidine, at a concentration of 0.2 to 1.6% reduces resident microflora populations from 90 to 99.98%[1]. A significant reduction in plaque score is observed on the buccal tooth surfaces after daily topical application of 1% solutions of octenidine and chlorhexidine for 7 d; octenidine is more effective than chlorhexidine[2]. | [References]
[1] A. Welk. “Antibacterial and antiplaque efficacy of a commercially available octenidine-containing mouthrinse.” Clinical Oral Investigations 20 1 (2015): 1469–1476.
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J & K SCIENTIFIC LTD.
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