| Identification | Back Directory | [Name]
tolmetin glucuronide | [CAS]
71595-19-2 | [Synonyms]
Tolmetin USP/EP/BP
tolmetin glucuronide
Tolmetin -D-Glucuronide
Tolmetin β-D-Glucuronide
Tolmetin-Beta-D-Glucuronide
Tolmetin acyl-β-D-glucuronide
Tolmetin acyl-β-D-glucuronide
TolMetin-acyl-beta-D-Glucuronide
Tolmetin acyl-beta-D-glucuronide, Min. 95%
1-[1-Methyl-5-(4-Methylbenzoyl)-1H-pyrrole-2-acetate]
1-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate]-D-Glucopyranuronic Acid
β-D-Glucopyranuronic acid, 1-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate]
(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetyl]oxyoxane-2-carboxylic acid | [Molecular Formula]
C21H23NO9 | [MOL File]
71595-19-2.mol | [Molecular Weight]
433.41 |
| Chemical Properties | Back Directory | [Melting point ]
139-142°C | [Boiling point ]
706.1±60.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
2.68±0.70(Predicted) | [color ]
White to Brown | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Description]
Tolmetin β-D-glucuronide is a major phase II metabolite of tolmetin . Tolmetin β-D-glucuronide has been classified into a ‘warning’ category in terms of its potential to cause idiosyncratic drug toxicity, based on its half-life in several in vitro systems. | [Chemical Properties]
Beige Solid | [Uses]
A metabolite of Tolmetin | [Uses]
A metabolite of Tolmetin. | [Definition]
ChEBI: Tolmetin glucuronide is a glucosiduronic acid. | [References]
[1] MARTHA L. HYNECK . High-performance liquid chromatographic determination of tolmetin, tolmetin glucuronide and its isomeric conjugates in plasma and urine[J]. Journal of Chromatography B: Biomedical Sciences and Applications, 1987, 420: Pages 349-356. DOI: 10.1016/0378-4347(87)80190-1
[2] RYOKO SAWAMURA. Predictability of idiosyncratic drug toxicity risk for carboxylic acid-containing drugs based on the chemical stability of acyl glucuronide.[J]. Drug Metabolism and Disposition, 2010, 38 10: 1857-1864. DOI: 10.1124/dmd.110.034173 |
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