| Identification | Back Directory | [Name]
N-(4-METHYLQUINAZOLIN-2-YL)GUANIDINE | [CAS]
716-11-0 | [Synonyms]
2-guanidino-4-methylquinazoline
1-(4-Methylquinazolin-2-yl)guanidine
2-(4-methyl-2-quinazolinyl)guanidine
2-(4-methylquinazolin-2-yl)guanidine
Guanidine, N-(4-methyl-2-quinazolinyl)- | [Molecular Formula]
C10H11N5 | [MDL Number]
MFCD00023908 | [MOL File]
716-11-0.mol | [Molecular Weight]
201.23 |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [HS Code ]
2933992000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
A positively charged guanidium-containing quinazoline that modulates ASIC function by blocking acid-induced maximal peak current as well as by altering ASICs pH dependence for activation and inactivation, enabling a partial, but sustained ASIC3 activation around neutral pH, which is inhibitable by Amiloride. Intraplantar paw injection (10 µL 100 µM) is reported to elicit a pain response in asic3+/+, but not asic3-/-, mice in vivo. GMQ targeting area appears to overlap with Amiloride binding site in the pore region, but is distinct from ASIC calcium binding site. | [Biological Activity]
Primary Target
ASIC3''Reversible: yes |
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