| Identification | Back Directory | [Name]
(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE | [CAS]
71636-61-8 | [Synonyms]
sk&f81297
(±)-6-Chloro-PB
SKF 81297 hydrobromi
SKF 81297 HYDROBROMIDE
(+/-)-SKF-81297 HYDROBROMIDE
(+/-)-6-CHLORO-PB HYDROBROMIDE
(+-)-6-CHLORO-PB HYDROBROMIDE (+-)-SKF-8 1297, HCL
2,3,4,5-Tetrahydro-6-chloro-1-phenyl-1H-3-benzazepine-7,8-diol
6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol
6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol
1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-
6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepinehydrobromide
6-CHLORO-2,3,4,5-TETRAHYDRO-1-PHENYL-1H-3-BENZAZEPINE-7,8-DIOL HYDROBROMIDE
(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
(±)-SKF-81297 hydrobromide, (±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide | [Molecular Formula]
C16H17BrClNO2 | [MDL Number]
MFCD00153782 | [MOL File]
71636-61-8.mol | [Molecular Weight]
370.67 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at +4°C | [solubility ]
H2O: 1.7 mg/mL | [form ]
solid | [color ]
gray | [Water Solubility ]
H2O: 1.7mg/mL
DMSO: >10mg/mL
ethanol: 6.3mg/mL | [InChI]
1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H | [InChIKey]
RMIJGBMRNYUZRG-UHFFFAOYSA-N | [SMILES]
Br[H].Oc1cc2C(CNCCc2c(Cl)c1O)c3ccccc3 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
22-26-36 | [WGK Germany ]
3 | [HS Code ]
2933990099 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal?regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats. | [Definition]
ChEBI:9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol is a benzazepine. | [Biological Activity]
Dopamine D 1 -like receptor agonist. Centrally active following systemic administration in vivo . | [Biochem/physiol Actions]
(+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist. | [in vivo]
SKF 81297 (0.05-0.3 mg/kg, i.m., once) stimulates motor behaviour of MPTP-lesioned monkeys[1]. | Animal Model: | Four male rhesus monkeys (Macaca mulatta, 7.0-11.3 kg)[1] | | Dosage: | 0.05-0.3 mg/kg | | Administration: | Injected intramuscularly (i.m.), once | | Result: | Significantly increased rotational behaviour and right-sided hand use in unilateral MPTP-lesioned rhesus monkeys. |
| [IC 50]
D1 Receptor |
|
| Company Name: |
Sigma-Aldrich
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