| Identification | Back Directory | [Name]
6-bromo-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol | [CAS]
71636-62-9 | [Synonyms]
SKF80723 HBr
SKF-80723 HBr
SKF 80723 HBr
SKF80723 Hydrobromide
SKF-80723 Hydrobromide
SKF 80723 Hydrobromide
6-bromo-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol | [EINECS(EC#)]
635-327-3 | [Molecular Formula]
C16H16BrNO2 | [MOL File]
71636-62-9.mol | [Molecular Weight]
334.208 |
| Hazard Information | Back Directory | [Description]
SKF-80723 HBr is a D1 receptor agonist. In rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the medial forebrain bundle, SKF-80723 HBr strongly potentiated the contralateral circling induced by quinpirole. | [Uses]
SKF-80723 is a D1 receptor agonist and can be used for study of Parkinson's disease[1][2]. | [References]
[1] Gnanalingham KK, et al. Selective dopamine antagonist pretreatment on the antiparkinsonian effects of benzazepine D1 dopamine agonists in rodent and primate models of Parkinson's disease--the differential effects of D1 dopamine antagonists in the primate. Psychopharmacology (Berl). 1995;117(4):403-412. DOI:10.1007/BF02246211
[2] Gnanalingham KK, et al. The differential behavioural effects of benzazepine D1 dopamine agonists with varying efficacies, co-administered with quinpirole in primate and rodent models of Parkinson's disease. Psychopharmacology (Berl). 1995;117(3):287-297. DOI:10.1007/BF02246103 |
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