| Identification | Back Directory | [Name]
3-Bromo-2-chloro-5-(trifluoromethyl)pyridine | [CAS]
71701-92-3 | [Synonyms]
3-Bromo-2-chloro-5-(trifluoromethyl)pyridine
Pyridine, 3-bromo-2-chloro-5-(trifluoromethyl)-
5-Bromo-6-chloro-alpha,alpha,alpha-trifluoro-3-picoline
3-Bromo-2-chloro-5-(trifluoromethyl)pyridine ISO 9001：2015 REACH | [Molecular Formula]
C6H2BrClF3N | [MDL Number]
MFCD09878432 | [MOL File]
71701-92-3.mol | [Molecular Weight]
260.44 |
| Chemical Properties | Back Directory | [Melting point ]
28-32℃ | [Boiling point ]
210.5±35.0 °C(Predicted) | [density ]
1.804±0.06 g/cm3(Predicted) | [Fp ]
98°(208°F) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
Solid | [pka]
-3.34±0.10(Predicted) | [color ]
Pale yellow to pale brown | [CAS DataBase Reference]
71701-92-3 |
| Hazard Information | Back Directory | [Synthesis]
A mixture of 3-bromo-5-(trifluoromethyl)pyridin-2-ol (37.75g, 0.16 mol) and phosphorus(lll) oxychloride (POCI3; 75 mL) is stirred at 1000C for 5 hours. After cooling to room temperature, the mixture is poured into ice-water and extracted with CH2CI2 twice. The combined organic layer is washed with NaHCO3 aq., brine, dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture is purified by flash column chromatography to give 3-bromo-2-chloro-5-trifluoromethylpyridine (31.90 g, 79 % yield) as a white solid.
| [References]
[1] Patent: WO2007/73934, 2007, A1. Location in patent: Page/Page column 75
[2] Patent: WO2008/58961, 2008, A1. Location in patent: Page/Page column 44; 45
[3] Patent: WO2008/58967, 2008, A1. Location in patent: Page/Page column 43; 44 |
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