| Identification | More | [Name]
2-Chloro-5-chloromethylpyridine | [CAS]
70258-18-3 | [Synonyms]
2,5-DICHLORO-4-METHYL-PYRIDINE
2-CHLORO-5-CHLOROMETHYLPYRIDINE
AKOS MSC-0759
AURORA KA-6694
TIMTEC-BB SBB003948
2-CHLORO-5-CHLOROMETHYLPYRIDINE 90%
2-Chloro-5-ChloroMethylPyridine(Ccmp)98%
2-Chloro-5-Chloro Methyl Pyridine (Ccmp) 98%
Pyridine, 2-chloro-5-(chloromethyl)-(9CI)
2-Chloro-5-chloromethylpyridine, tech., 90%
imidacloprid impurity
2-CHLORO-5-(CHLOROMETHYL)PYRIDINE[FOR IMIDACLOPRID]
2-CHLORO-5-CHLOROMETHYLPYRIDINE 2-CHLORO-5-CHLOROMETHYLPYRIDINE
2-CHLORO-5-CHLOROMETHYLPYRIDINE, 90%, TECH. | [EINECS(EC#)]
615-091-8 | [Molecular Formula]
C6H5Cl2N | [MDL Number]
MFCD00125366 | [Molecular Weight]
162.02 | [MOL File]
70258-18-3.mol |
| Chemical Properties | Back Directory | [Appearance]
beige moist crystals | [Melting point ]
37-42 °C(lit.)
| [Boiling point ]
267.08°C (rough estimate) | [density ]
1.4411 (rough estimate) | [refractive index ]
1.6000 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Moist Crystals | [pka]
-0.75±0.10(Predicted) | [color ]
Beige | [Water Solubility ]
Insoluble in water. | [BRN ]
1635690 | [InChI]
InChI=1S/C6H5Cl2N/c7-3-5-1-2-6(8)9-4-5/h1-2,4H,3H2 | [InChIKey]
SKCNYHLTRZIINA-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=C(CCl)C=C1 | [CAS DataBase Reference]
70258-18-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H302-H314 | [Precautionary statements ]
P260-P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P305+P351+P338 | [Hazard Codes ]
C,Xi,F | [Risk Statements ]
R22:Harmful if swallowed.
R34:Causes burns.
R36:Irritating to the eyes.
R10:Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S25:Avoid contact with eyes .
S36:Wear suitable protective clothing .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [Hazard Note ]
Corrosive/Harmful | [HazardClass ]
8 | [HazardClass ]
LACHRYMATOR, CORROSIVE | [PackingGroup ]
II | [HS Code ]
29333999 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Acute Tox. 4 Oral
Skin Corr. 1B |
| Questions And Answer | Back Directory | [Description]
2-Chloro-5-chloromethylpyridine is used for the synthesis of various pharmaceutical compounds. It can also be used for the synthesis of new neonicotinoid compounds1, having insecticidal activity. It is the raw material of pesticide products such as imidacloprid, acetamiprid as well as bactericide and herbicide2,3.
| [Structure]
2-Chloro-5-(chloromethyl)pyridine, C6H5Cl2N, is almost planar, with an r.m.s. deviation of 0.0146 Å for all atoms except for the 5-choloromethyl Cl atom. The offset Cl atom lies above this plane with a Cl—C—C angle of 111.11 (17)°. In the crystal, molecules are connected via intermolecular C—H⋯N hydrogen bonds, forming dimers. The crystals were obtained by dissolving 2-Chloro-5-(chloromethyl)pyridine (0.2 g, 1.2 mmol) in ethanol (25 ml) and evaporating the solvent slowly at room temperature for about 5 d[1].
 | [Sources]
- https://www.alfa.com/en/catalog/L19284/
- https://www.trc-canada.com/product-detail/?C364715
- www.szqhbio.com/wap_news_detailen/id/1.htm
|
| Hazard Information | Back Directory | [Chemical Properties]
beige moist crystals | [Uses]
2-Chloro-5-(chloromethyl)pyridine is used for the synthesis of various pharmaceutical compounds. It can also be used for the synthesis of new neonicotinoid compounds. | [Synthesis]
General procedure for the synthesis of 2-chloro-5-chloromethylpyridine from the compound (CAS:150807-86-6): 18 g (0.1 mol) of 2-chloro-2-chloromethyl-4-cyano-butanal was dissolved in 50 ml of toluene, and 33 g (1.1 eq.) of solid phosgene was added to the toluene solution. The reaction mixture was stirred at 50°C for 5 hours. Upon completion of the reaction, the mixture was cooled to facilitate crystallization to afford the acetamiprid intermediate 2-chloro-5-chloromethylpyridine in 97% yield. Subsequently, the acetamiprid prodrug was further synthesized in 95% yield through methylation and esterification reaction steps. | [References]
[1] Zhi-Qiang Feng. “2-Chloro-5-(chloro-meth-yl)pyridine.” Acta crystallographica. Section E, Structure reports online 67 Pt 2 (2011): o366.
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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