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71812-08-3

71812-08-3 Structure

71812-08-3 Structure
IdentificationBack Directory
[Name]

Herquline A
[CAS]

71812-08-3
[Synonyms]

Herquline A
Herquilne A
[Molecular Formula]

C19H26N2O2
[MOL File]

71812-08-3.mol
[Molecular Weight]

314.422
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: soluble; Ethanol: soluble; Methanol: soluble
[form ]

A solid
Hazard InformationBack Directory
[Description]

Herquline A is an alkaloid fungal metabolite originally isolated from P. herquei. It inhibits cell death induced by influenza A strain A/PR/8/34 in MDCK cells with an IC50 value of 10 μg/ml and inhibits viral replication in a plaque assay in a concentration-dependent manner. Herquline A also inhibits platelet aggregation induced by ADP and platelet-activating factor (PAF) in vitro (IC50s = 180 and 240 μM, respectively).
[Uses]

Herquline A is an alkaloid produced by Penicillium herquei. It is an antiviral agent that inhibits influenza virus replication.Herquline A is also a platelet aggregation inhibitor.
[References]

[1] Y ENOMOTO. Herquline B, a new platelet aggregation inhibitor produced by Penicillium herquei Fg-372.[J]. Journal of Antibiotics, 1996, 49 1: 50-53. DOI: 10.7164/antibiotics.49.50
[2] TAKUYA CHIBA. Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties[J]. Bioscience, Biotechnology, and Biochemistry, 2017, 24 1: 59-62. DOI: 10.1080/09168451.2016.1162084
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