| Identification | Back Directory | [Name]
1-(4-carboxyphenyl)-3,3-dimethyltriazene | [CAS]
7203-91-0 | [Synonyms]
CB10-277
1-(4-carboxyphenyl)-3,3-dimethyltriazene
Benzoic acid, 4-(3,3-dimethyl-1-triazen-1-yl)- | [Molecular Formula]
C9H11N3O2 | [MOL File]
7203-91-0.mol | [Molecular Weight]
193.2 |
| Hazard Information | Back Directory | [Uses]
CB10-277 is a Dacarbazine (HY-B0078) analog that mediates alkylation of guanine residues at the O6 position in DNA and subsequently reduces ATase levels in lymphocytes and tumors. CB10-277 is useful in the study of metastatic malignant melanoma[1]. | [References]
[1] Siow Ming, et al. "In vivo depletion of O 6-alkylguanine-DNA-alkyltransferase in lymphocytes and melanoma of patients treated with CB 10-277, a new DTIC analogue." Cancer chemotherapy and pharmacology 31 (1992): 240-246. DOI:10.1007/BF00685554 |
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