| Identification | Back Directory | [Name]
3-CHLORO-2-METHYLPYRIDINE | [CAS]
72093-03-9 | [Synonyms]
3-CHLORO-2-PICOLINE
3-CHLORO-2-METHYLPYRIDINE
Pyridine, 3-chloro-2-methyl-
Pyridine, 3-chloro-2-methyl- (9CI)
3-CHLORO-2-METHYLPYRIDINE ISO 9001：2015 REACH | [EINECS(EC#)]
675-785-1 | [Molecular Formula]
C6H6ClN | [MDL Number]
MFCD04114121 | [MOL File]
72093-03-9.mol | [Molecular Weight]
127.57 |
| Chemical Properties | Back Directory | [Boiling point ]
156.5±20.0 °C(Predicted) | [density ]
1.150±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
3.67±0.10(Predicted) | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-chloro-2-methylpyridine from 3-amino-2-methylpyridine: 54 g of 3-amino-2-methylpyridine was slowly added to 130 g of concentrated hydrochloric acid (36-38% mass fraction). Subsequently, hydrogen chloride gas was passed to saturation and 222.45 g of phosphoryl chloride and 90 g of nitric acid at 70% mass concentration were added dropwise at 20-25°C. The reaction was carried out with continuous stirring and strict stirring. The reaction was carried out with continuous stirring and under strict temperature control. After completion of the reaction, 57.3 g of 3-chloro-2-methylpyridine was obtained in 89% yield and 99% purity after post-treatment. | [References]
[1] Patent: CN105061300, 2018, B. Location in patent: Paragraph 0020; 0021 |
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