| Identification | Back Directory | [Name]
2-(4-Chlorophenyl)thiazole-5-carbaldehyde | [CAS]
721920-84-9 | [Synonyms]
2-(4-CHLOROPHENYL)THIAZOLE-5-CARBALDEHYDE
2-(4-hydroxyphenyl)thiazole-5-carbaldehyde
5-Thiazolecarboxaldehyde, 2-(4-chlorophenyl)-
2-(4-chlorophenyl)-1,3-thiazole-5-carbaldehyde | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C10H6ClNOS | [MDL Number]
MFCD05864657 | [MOL File]
721920-84-9.mol | [Molecular Weight]
223.68 |
| Chemical Properties | Back Directory | [Boiling point ]
377.6±48.0 °C(Predicted) | [density ]
1.388±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
0.14±0.10(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
Step 1. Synthesis of 2-(4-chlorophenyl)-1,3-thiazole-5-carbaldehyde. 4-Chlorobenzamide (5 g, 29.1 mmol), magnesium bicarbonate pentahydrate (7.06 g, 14.55 mmol) and 2-chloromalonaldehyde (4.65 g, 43.65 mmol) were added to a flask and the reaction was stirred for 3 hr at 60 °C under nitrogen protection. Upon completion of the reaction, the reaction mixture was allowed to pass through a silica plug for rapid column chromatography and washed with ethyl acetate. The solvent was removed by concentration under reduced pressure to afford the target product 2-(4-chlorophenyl)-1,3-thiazole-5-carbaldehyde (6 g, 92% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 10.06 (s, 1H), 8.43 (s, 1H), 7.99-7.96 (m, 2H), 7.49-7.46 (m, 2H). | [References]
[1] Patent: WO2004/58761, 2004, A1. Location in patent: Page 37-38
[2] Patent: WO2011/12862, 2011, A1. Location in patent: Page/Page column 102; 109 |
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