| Identification | More | [Name]
Fosthiazate | [CAS]
98886-44-3 | [Synonyms]
FOSTHIAZATE
NEMATHORIN
O-ETHYL S-(1-METHYLPROPYL) 2-OXO-3-THIAZOLIDINYLPHOSPHONOTHIOATE
S-SEC-BUTYL O-ETHYL 2-OXO-3-THIAZOLIDINYLPHOSPHONOTHIOATE
(2-oxo-3-thiazolidinyl)-phosphonothioicacio-ethyls-(1-methylpropyl)este
asc-66824
iki1145
s-sec-butylo-ethyl(2-oxo-1,3-thiazolidine-3-yl)phosphonothioate
(RS)-S-sec-butyl-O-ethyl-2-oxo-1,3--thiazolodin-3-ylphosphonothioate
O-ethyl-S-(1-methyl-propyl)(2-oxo-3-thiazolodinyl)phosphonothioate
FOSTHISZATE
fosthiazate (bsi,draft e-iso)
O-Ethyl S-(1-methylpropyl) 2-oxo-3-hiazolidinylphosphonothioate
fosthiazate (ISO) (RS)-S-sec-butyl-O-ethyl-2-oxo-1,3-thiazolidin-3-ylphosphonothioate
O-Ethyl S-(1-methylpropyl) 2-oxo-3-hiazolidinylphosphonothioate, S-sec-Butyl O-ethyl 2-oxo-3-thiazolidinylphosphonothioate
O-ethyl-S-sec-buty1-2-oxo-1, 3-thiazolidin-3-y1 phosphonothioate
(2-Oxothiazolidin-3-yl)thiophosphonic acid S-sec-butyl O-ethyl ester | [EINECS(EC#)]
-0 | [Molecular Formula]
C9H18NO3PS2 | [MDL Number]
MFCD00274595 | [Molecular Weight]
283.35 | [MOL File]
98886-44-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
<25 °C | [Boiling point ]
bp0.5 198° | [density ]
1.26±0.1 g/cm3(Predicted) | [refractive index ]
n19.6D 1.5334 | [storage temp. ]
0-6°C | [solubility ]
Chloroform (Slightly), Water (Slightly) | [form ]
neat | [pka]
-2?+-.0.20(Predicted) | [color ]
White to off-white | [Henry's Law Constant]
7.5×101 mol/(m3Pa) at 25℃, MacBean (2012) | [Stability:]
Hygroscopic | [Major Application]
agriculture
environmental | [InChI]
InChI=1S/C9H18NO3PS2/c1-4-8(3)16-14(12,13-5-2)10-6-7-15-9(10)11/h8H,4-7H2,1-3H3 | [InChIKey]
DUFVKSUJRWYZQP-UHFFFAOYSA-N | [SMILES]
P(N1CCSC1=O)(SC(C)CC)(=O)OCC | [CAS DataBase Reference]
98886-44-3(CAS DataBase Reference) | [EPA Substance Registry System]
98886-44-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,N | [Risk Statements ]
R21:Harmful in contact with skin.
R23/25:Toxic by inhalation and if swallowed .
R39:Danger of very serious irreversible effects.
R41:Risk of serious damage to eyes.
R43:May cause sensitization by skin contact.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S25:Avoid contact with eyes .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2810 | [WGK Germany ]
3 | [RTECS ]
TB1707000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29341000 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Dam. 1
Skin Sens. 1 | [Hazardous Substances Data]
98886-44-3(Hazardous Substances Data) | [Toxicity]
LD50 in male, female mice, male, female rats (mg/kg): 104, 91, 73, 57 orally; in male, female rats (mg/kg): 2396, 861 dermally. LC50 in male, female rats (mg/l): 0.832, 0.558 by inhalation (Toki). |
| Hazard Information | Back Directory | [Description]
Fosthiazate is an organothiophosphate insecticide used to control nematodes and sucking / chewing insects. It is highly soluble in water, is not volatile and is not usually persistent in soil systems but may be in some water systems. It has a high mammalian oral toxicity but may be a neurotoxin. It is highly toxic to most terrestrial biodiversity but moderately toxic to most aquatic species. | [Uses]
Nematicide. | [Uses]
thiazolidin e thione pharmaceutical intermediate | [Definition]
ChEBI: Fosthiazate is a phosphonic ester, an organic phosphonate and an organothiophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an agrochemical and a nematicide. | [Production Methods]
Commercial production of fosthiazate typically begins with the synthesis of its organophosphorus backbone, involving the reaction of phosphorothioate derivatives with alcohols and heterocyclic intermediates. A key step includes forming the thiazolidinone ring, which is then coupled with the phosphorus-containing moiety to yield the active nematicidal compound. The process requires precise control over reaction conditions to ensure the correct stereochemistry. | [Agricultural Uses]
Insecticide, Nematicide: Systemic pesticide applied to the soil. | [Trade name]
CGA 41065®; IKI 1145®; NEMATHORIN®;
PREMEIR®; PRIME® | [Mechanism of action]
Systemic. Acetylcholinesterase (AchE) inhibitor. | [Pesticide Type]
Insecticide; Nematicide |
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