| Identification | Back Directory | [Name]
N-succinimidyl-4-((iodoacetyl)amino)benzoate | [CAS]
72252-96-1 | [Synonyms]
N-succinimidyl-(4-iodoacetamido)benzoate
4-[(2-Iodoacetyl)aMino]benzoic Acid 2,5-dioxo-1-pyrrolidinyl Ester
N-[4-[[(2,5-Dioxopyrrolidin-1-yl)oxy]carbonyl]phenyl]-2-iodoacetamide | [Molecular Formula]
C13H11IN2O5 | [MDL Number]
MFCD00078537 | [MOL File]
72252-96-1.mol | [Molecular Weight]
402.14 |
| Chemical Properties | Back Directory | [Melting point ]
19-7-200°C (dec.) | [density ]
1.87±0.1 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
Acetontrile (Slightly), DMSO (Slightly) | [form ]
Solid | [pka]
12.16±0.70(Predicted) | [color ]
Pale Yellow | [InChI]
1S/C13H11IN2O5/c14-7-10(17)15-9-3-1-8(2-4-9)13(20)21-16-11(18)5-6-12(16)19/h1-4H,5-7H2,(H,15,17) | [InChIKey]
BQWBEDSJTMWJAE-UHFFFAOYSA-N | [SMILES]
O=C(CCC1=O)N1OC(C2=CC=C(NC(CI)=O)C=C2)=O |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent.
Spacer Arm: 10.6 Angstroms | [General Description]
SIAB is an amine- and sulfhydryl-reactive heterobifunctional crosslinker and Sulfo-SIAB is its water-soluble analog. These crosslinkers contain an amine-reactive N-hydroxysuccimide (NHS) ester and a sulfhydryl-reactive iodoacetyl group, and are often used for preparing enzyme conjugates or immunotoxins. Water-soluble and water-insoluble forms of NHS esters have essentially identical reactivity. Sulfo-SIAB is supplied as a sodium salt and is water-soluble to ~10mM. SIAB must be first dissolved in an organic solvent, such as DMSO or DMF, and then added to the aqueous reaction mixture. SIAB is lipophilic, membrane-permeable and does not possess a charged group. | [reaction suitability]
reagent type: cross-linking reagent |
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Henan Alfachem Co.,Ltd.
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