| Identification | Back Directory | [Name]
ACIFRAN | [CAS]
72420-38-3 | [Synonyms]
ay25712
ACIFRAN
Acifranum
4,5-dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylicaci
4,5-DIHYDRO-5-METHYL-4-OXO-5-PHENYL-2-FURANCARBOXYLIC ACID
4,5-Dihydro-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid
5-Methyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxylic acid
2-Furancarboxylic acid, 4,5-dihydro-5-methyl-4-oxo-5-phenyl-
(R,S)-4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid | [Molecular Formula]
C12H10O4 | [MDL Number]
MFCD00865746 | [MOL File]
72420-38-3.mol | [Molecular Weight]
218.21 |
| Chemical Properties | Back Directory | [Melting point ]
176° | [Boiling point ]
378.4±42.0 °C(Predicted) | [density ]
1.343±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Soluble in DMSO > 10 mM | [form ]
Powder | [pka]
2.25±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Acifran is a nicotinic acid receptor agonist. | [Uses]
Antihyperlipopro-teinemic. | [Brand name]
Reductol (Wyeth-Ayerst). | [Biological Activity]
Hypolipidaemic agent; more potent than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC 50 values are 1.3? and 4.2 μ M respectively). In vivo, reduces serum triglycerides and circulating LDL-cholesterol without affecting liver weight or liver enzymes. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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