72420-38-3

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72420-38-3 Structure

Identification	Back Directory
[Name] ACIFRAN
[CAS] 72420-38-3
[Synonyms] ay25712 ACIFRAN Acifranum 4,5-dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylicaci 4,5-DIHYDRO-5-METHYL-4-OXO-5-PHENYL-2-FURANCARBOXYLIC ACID 4,5-Dihydro-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid 5-Methyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxylic acid 2-Furancarboxylic acid, 4,5-dihydro-5-methyl-4-oxo-5-phenyl- (R,S)-4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid
[Molecular Formula] C12H10O4
[MDL Number] MFCD00865746
[MOL File] 72420-38-3.mol
[Molecular Weight] 218.21

Chemical Properties	Back Directory
[Melting point ] 176°
[Boiling point ] 378.4±42.0 °C(Predicted)
[density ] 1.343±0.06 g/cm3(Predicted)
[storage temp. ] Store at +4°C
[solubility ] Soluble in DMSO > 10 mM
[form ] Powder
[pka] 2.25±0.40(Predicted)
[color ] Off-white to light yellow

Hazard Information	Back Directory
[Uses] Acifran is a nicotinic acid receptor agonist.
[Uses] Antihyperlipopro-teinemic.
[Brand name] Reductol (Wyeth-Ayerst).
[Biological Activity] Hypolipidaemic agent; more potent than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC 50 values are 1.3? and 4.2 μ M respectively). In vivo, reduces serum triglycerides and circulating LDL-cholesterol without affecting liver weight or liver enzymes.
[storage] Store at -20°C

Safety Data	Back Directory
[Toxicity] LD50 orally in rats: 3 g/kg (Jirkovsky, 1982)

Spectrum Detail	Back Directory
[Spectrum Detail] ACIFRAN(72420-38-3)¹HNMR

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