| Identification | Back Directory | [Name]
N-BUTYLDEOXYNOJIRIMYCIN | [CAS]
72599-27-0 | [Synonyms]
nb-dnj
OGT 918
Zavesca
SC-48334
Mg gross
N-Butylmoranoline
N-BUTYLDEOXYNOJIRIMYCIN
N-BUTYL-1-DEOXYNOJIRIMYCIN
Miglustat hydrochloride salt
N-(n-Butyl)-1-deoxynojirimycin
Miglustat (N-Butyldeoxynojirimycin)
1,5-(Butylimino)-1,5-dideoxy-D-glucitol
N-(n-Butyl)-1-deoxynojirimycin min. 99%
MIGLUSTAT;N-BUTYLDEOXYNOJIRIMYCIN;NB-DNJ;OGT918
N-BUTYLDEOXYNOJIRIMYCIN;SC-48334;NB-DNJ;OGT-918
1-Butyl-3β,4α,5β-trihydroxypiperidine-2α-methanol
1-Butyl-2α-(hydroxymethyl)piperidine-3β,4α,5β-triol
(2R)-1-Butyl-2α-(hydroxymethyl)piperidine-3β,4α,5β-triol
(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol
3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, (2R,3R,4R,5S)-
N-Butyldeoxynojirimycin, Hydrochloride - CAS 72599-27-0 - Calbiochem
Miglustat, NB-DNJ, (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
Hot Sale 3, 4, 5-Piperidinetriol, 1-Butyl-2- (hydroxymethyl) -, (2R, 3R, 4R, 5S) N-BUTYLDEOXYNOJIRIMYCIN | [EINECS(EC#)]
207-526-1 | [Molecular Formula]
C10H21NO4 | [MDL Number]
MFCD00272581 | [MOL File]
72599-27-0.mol | [Molecular Weight]
219.28 |
| Questions And Answer | Back Directory | [Synthesis]
Based on the Mannich reaction mechanism, N-propyldeoxynojirimycin was synthesized from 1-deoxynojirimycin as the starting material. The synthetic reaction formula for N-Butyldeoxynojirimycin is shown in the figure below: 
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| Chemical Properties | Back Directory | [Melting point ]
126-127℃ | [alpha ]
D25 -15.9° (c = 0.77 in water) | [Boiling point ]
394.7±42.0 °C(Predicted) | [density ]
1.234 | [RTECS ]
TN4350150 | [storage temp. ]
2-8°C | [solubility ]
DMSO 44 mg/mL (200.66 mM) Ethanol 22 mg/mL (100.33 mM) Water 44 mg/mL (200.66 mM) | [form ]
Powder | [pka]
13.72±0.70(Predicted) | [color ]
White | [Water Solubility ]
Soluble in water at 10mg/ml | [InChI]
InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | [InChIKey]
UQRORFVVSGFNRO-UTINFBMNSA-N | [SMILES]
N1(CCCC)C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |
| Hazard Information | Back Directory | [Description]
Miglustat is an N-alkylated iminosugar, launched as an oral treatment for mild to
moderate type 1 Gaucher’s disease in adult patients for whom enzyme replacement
therapy is not a therapeutic option. It is readily synthesized from D-glucose in three steps by first converting to N-butylglucamine via reductive amination with
butylamine, followed by a microbial oxidation to an aminofuranose intermediate
and subsequent reductive cyclization. Type 1 Gaucher’s disease is a metabolic
disorder caused by the lysosomal accumulation of certain glycosphingolipids (GSLs)
as a result of deficiency in their degradation. Enlargement of the liver and spleen,
low blood platelet and bone lesions are among the key symptoms of this disease.
Miglustat acts by inhibiting glucosylceramide synthase, a glucosyl transferase
enzyme in the biosynthesis of most GSLs, which results in the lowering of GSLs to
a level that can be effectively cleared. Up to 50% reduction in liver and splenocyte
GSL levels are achieved in mice by long-term administration of Miglustat (600–
1800 mg/kg/day for 118 days). Miglustat, dosed at 50 and 100 mg in Gaucher
patients, exhibits dose proportionate pharmacokinetics (tmax=2.5 h, t1/2=6 to 7 h)
and ＞90% oral bioavailability. Steady-state plasma levels are reached after 4–6
weeks of treatment. Miglustat is not significantly metabolized in humans and the
major route of excretion is renal. In clinical trials, efficacy was demonstrated by
significant reductions in liver and spleen volumes (12 and 19%, respectively) at 12
months and increase in hemoglobin and platelet count (0.91 g/dL and 13.6×109/l,
respectively) at 24 months. Miglustat is generally well tolerated by patients and the
most common side effects are diarrhea and weight loss. | [Originator]
G.D. Searle (Pfizer) (US) | [Uses]
Treatment of glycolipid storage diseases. | [Definition]
ChEBI: A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group. | [Indications]
N-butyldeoxynojirimycin is an approved drug for Niemann–Pick disease type C and Gaucher disease type 1, which are lipid storage disorders[1].
| [Brand name]
Zavesca(Actelion);Vevesca. | [General Description]
N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin. | [Biological Activity]
Orally active α -glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CTFR in human airway epithelial cells via inhibition of ER α -glucosidases I and II. Also has broad spectrum antiviral activity. | [Biochem/physiol Actions]
N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease. | [storage]
Store at -20°C | [References]
[1] Hiroyuki Nakamura . “N-butyldeoxynojirimycin (miglustat) ameliorates pulmonary fibrosis through inhibition of nuclear translocation of Smad2/3.” Biomedicine & Pharmacotherapy 160 (2023): Article 114405.
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| Company Name: |
LETOPHARM LIMITED
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| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
Sigma-Aldrich
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| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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