| Identification | Back Directory | [Name]
Methyl 1-Aminocyclopropanecarboxylate | [CAS]
72784-43-1 | [Synonyms]
ACPCM
Methyl 1-Aminocyclopropanecarboxylate
Methyl 1-amino-1-cyclopropylcarboxylate
Methyl 1-aminocyclopropane-1-carboxylate
Methyl 1-Aminocyclopropanecarboxylate USP/EP/BP
Cyclopropanecarboxylic acid, 1-aMino-, Methyl ester | [Molecular Formula]
C5H9NO2 | [MDL Number]
MFCD00906963 | [MOL File]
72784-43-1.mol | [Molecular Weight]
115.13 |
| Chemical Properties | Back Directory | [Boiling point ]
136℃ | [density ]
1.188 | [Fp ]
12℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [form ]
liquid | [pka]
6.01±0.20(Predicted) | [color ]
Light yellow |
| Hazard Information | Back Directory | [Synthesis]
Sulfoxide chloride (8.8 g, 75.1 mmol) was slowly added dropwise to methanol (50 mL) at 0 °C, followed by a one-time addition of 1-aminocyclopropanecarboxylic acid (5.0 g, 49.8 mmol). The reaction mixture was heated to reflux for 1 to 3 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to afford methyl 1-aminocyclopropanecarboxylate hydrochloride (5.8 g, 100% yield). | [References]
[1] Patent: WO2011/69063, 2011, A2. Location in patent: Page/Page column 84
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 10, p. 2785 - 2788
[3] Patent: US2016/24031, 2016, A1. Location in patent: Paragraph 0598
[4] Bulletin of the Chemical Society of Japan, 1986, vol. 59, # 9, p. 2839 - 2842
[5] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 10, p. 3345 - 3355 |
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