72784-42-0

67-56-1

22059-21-8

72784-42-0

1. A methanolic solution of acetyl chloride (10 mL) was prepared by slowly adding acetyl chloride (10 mL) dropwise to methanol (10 mL) under stirring conditions. 2. The methanolic solution of acetyl chloride prepared as above was added dropwise to a methanolic (20 mL) suspension of 1-aminocyclopropanecarboxylic acid (2.5 g, 24.7 mmol). 3. The reaction mixture was heated and refluxed for 16 h. 4. After completion of the reaction, the reaction solution was cooled to room temperature and subsequently concentrated under reduced pressure to give 1-aminocyclopropanecarboxylic acid methyl ester hydrochloride (3.77 g, 100 %). 5. The reaction solution was cooled to room temperature and subsequently concentrated under reduced pressure to afford methyl 1-aminocyclopropanecarboxylate hydrochloride (3.77 g, 100% yield). 5. The structure of the product was confirmed by mass spectrometry (MS) analysis with m/z = 116.2 (calculated value of 115.1 for C5H9NO2). 6. The resulting product can be used directly in subsequent experiments without further purification.