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73024-95-0

73024-95-0 Structure

73024-95-0 Structure
IdentificationBack Directory
[Name]

MET-ENKEPHALIN-ARG-PHE
[CAS]

73024-95-0
[Synonyms]

MERF
MEAP
Met-Enkephalin-RF
MET-ENKEPHALIN-ARG-PHE
[Met5]enkephalyl-Arg-Phe
Met-Enkephalin-Arg-Phe MERF
arg(6)-phe(7)-enkephalin-me
TYR-GLY-GLY-PHE-MET-ARG-PHE
[MET5,ARG6,PHE7] ENKEPHALIN
Tyr-Gly-Gly-Phe-Arg-Arg-Phe
METHIONINE ENKEPHALIN-ARG,PHE
Tyr-Gly-Gly-Phe-Met-Arg-Phe-OH
enkephalin-Met, Arg(6)-Phe(7)-
H-TYR-GLY-GLY-PHE-MET-ARG-PHE-OH
L-Tyr-Gly-Gly-L-Phe-L-Met-L-Arg-L-Phe-OH
methionine enkephalin-arg-phe acetate hydrate
Methionine Enkephalin-Arg-Phe acetate salt hydrate
Met-Enkephalin-Arg-Phe H-Tyr-Gly-Gly-Phe-Met-Arg-Phe-OH
L-Phenylalanine, L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-
[EINECS(EC#)]

-0
[Molecular Formula]

C42H56N10O9S
[MDL Number]

MFCD00076425
[MOL File]

73024-95-0.mol
[Molecular Weight]

877.02
Chemical PropertiesBack Directory
[density ]

1.38±0.1 g/cm3(Predicted)
[storage temp. ]

-15°C
[pka]

3.49±0.10(Predicted)
[Sequence]

Tyr-Gly-Gly-Phe-Met-Arg-Phe
Hazard InformationBack Directory
[Uses]

Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity[1].
[Definition]

ChEBI: Met-enkephalin-Arg-Phe is an organic molecular entity.
[in vivo]

Met-Enkephalin-Arg-Phe (10-100 nmol/mouse; i.c.v.; once) shows analgesic activity in mice[1].

Animal Model:Male Swiss Webster mice[1]
Dosage:10-100 nmol/mouse
Administration:Intracerebralventricular injection, once
Result:Produced a dose-related inhibition of the tail-flick response. The effects peaked at 2-4 min and were dissipated by 10 min. The EC50 was 38.5 nmol/mouse.
[References]

[1] Inturrisi CE, et al. Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5512-4. DOI:10.1073/pnas.77.9.5512
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