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73220-03-8

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73220-03-8 Structure

73220-03-8 Structure
IdentificationBack Directory
[Name]

REMOXIPRIDE HYDROCHLORIDE
[CAS]

73220-03-8
[Synonyms]

CV236900
(s)-(-)-d
(-)-fla732
REMOXIPRIDE HYDROCHLORIDE
(S)-ReMoxipride Hydrochloride
Remoxipride Hydrochloride (anhydrous)
3-bromo-2,6-dimethoxy-n-(1-ethyl-2-pyrrolidinylmethyl)-benzamidhydrochlori
S-(-)-3-BROMO-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2,6-DIMETHOXYBENZAMIDE HCL
(s)-(-)-2-((3-bromo-2,6-dimethoxybenzamido)methyl)-1-ethylpyrrolidinehydroch
(s)-(-)-3-bromo-2,6-dimethoxy-n-(1-ethyl-2-pyrrolidinylmethyl)benzamidehydro
(-)-(S)-3-Brom-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,6-dimethoxybenzamide hydrochloride
(S)-(-)-3-BROMO-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]2,6-DIMETHOXYBENZAMIDE HYDROCHLORIDE
(S)-(-)-3-BROMO-N-[(1-ETHYL-2-PYRROLIDINYL0METHYL]2,6-DIMETHOXYBENZAMIDE HYDROCHLORIDE
[Molecular Formula]

C16H24BrClN2O3
[MDL Number]

MFCD01743944
[MOL File]

73220-03-8.mol
[Molecular Weight]

407.73
Chemical PropertiesBack Directory
[Melting point ]

168-169 °C
[storage temp. ]

Store at RT
[solubility ]

Chloroform (Sparingly), Water (Slightly, Sonicated)
[form ]

White solid.
[color ]

White to Off-White
[Water Solubility ]

Soluble to 100 mM in water
[Stability:]

Hygroscopic
Hazard InformationBack Directory
[Uses]

Specific dopamine D2-receptor antagonist. Antipsychotic.
[Biological Activity]

Standard D 2 receptor antagonist showing some selectivity over D 3 and D 4 receptors (K i values are ~ 300, ~ 1600, and ~ 2800 nM for D 2 , D 3 and D 4 receptors respectively). In vivo remoxipride is an antipsychotic which does not cause extrapyramidal side effects and is 50-fold more potent than sulpiride in antagonising the effects of apomorphine in the rat.
[in vivo]

(S)-Remoxipride hydrochloride (0.1-100 μM/kg; i.p. 60 min prior to apomorphine) blockades apomorphine-induced behaviors s in rats and vomiting in dogs[1]. (S)-Remoxipride hydrochloride (0.1-10 mg/kg; i.p. 30 min prior to apomorphine) displaces [3H]spiperone from both striatal and extra-striatal areas[1].

Spectrum DetailBack Directory
[Spectrum Detail]

REMOXIPRIDE HYDROCHLORIDE(73220-03-8)1HNMR
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