| Identification | Back Directory | [Name]
2-METHYL-1-(4-NITROPHENYL)-1H-IMIDAZOLE | [CAS]
73225-15-7 | [Synonyms]
1-(4-nitrophenyl)-2-Methylimidazole
2-METHYL-1-(4-NITROPHENYL)-1H-IMIDAZOLE
1H-Imidazole, 2-methyl-1-(4-nitrophenyl)-
2-Methyl-1-(4-nitrophenyl)-1H-imidazole95% | [Molecular Formula]
C10H9N3O2 | [MDL Number]
MFCD06797789 | [MOL File]
73225-15-7.mol | [Molecular Weight]
203.2 |
| Chemical Properties | Back Directory | [Melting point ]
138-139 °C | [Boiling point ]
396.5±44.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
6.17±0.10(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
General procedure: 1-fluoro-4-nitrobenzene (10 g, 70.9 mmol), 2-methyl-1H-imidazole (5.8 g, 70.9 mmol) and cesium carbonate (Cs2CO3, 34.7 g, 106.4 mmol) were placed in degassed N,N-dimethylformamide (DMF, 200 mL). The mixture was heated to 100 °C and stirred overnight under nitrogen protection. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of 1-fluoro-4-nitrobenzene, the reaction mixture was concentrated under reduced pressure. Water (300 mL) was added to the concentrated residue and a gray precipitate was precipitated, which was separated by filtration to afford the target compound 2-methyl-1-(4-nitrophenyl)-1H-imidazole (12.8 g, 89% yield). | [References]
[1] Advanced Synthesis and Catalysis, 2016, vol. 358, # 4, p. 597 - 609
[2] Patent: WO2011/75478, 2011, A1. Location in patent: Page/Page column 53
[3] Patent: WO2009/71888, 2009, A1. Location in patent: Page/Page column 83
[4] Patent: US5298520, 1994, A
[5] Journal of Medicinal Chemistry, 1995, vol. 38, # 10, p. 1799 - 1810 |
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