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732983-37-8

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732983-37-8 Structure

732983-37-8 Structure
IdentificationBack Directory
[Name]

BAY 61-3606
[CAS]

732983-37-8
[Synonyms]

CS-2745
BAY-61-360
BAY 61-3606
SYK INHIBITOR IV
BAY 61-3606 free base
Syk Inhibitor IV, BAY 61-3606
Syk Inhibitor IV, BAY 61-3606 HCl
BAY 61-3606 hydrate hydrochloride
Syk Inhibitor IV, BAY 61-3606: sc-202351 hydrochloride
2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide
3-Pyridinecarboxamide, 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-
[Molecular Formula]

C20H18N6O3
[MDL Number]

MFCD18641826
[MOL File]

732983-37-8.mol
[Molecular Weight]

390.4
Chemical PropertiesBack Directory
[density ]

1.41
[storage temp. ]

2-8°C
[solubility ]

H2O: soluble
[form ]

solid
[color ]

yellow
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Syk Inhibitor IV is an imidazopyrimidine inhibitor of Syk and Syk-mediated functions.
[Definition]

ChEBI: 2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide is a member of pyrimidines.
[Biological Activity]

Cell permeable: yes''Primary Target
Syk''Product competes with ATP.''Reversible: yes
[in vivo]

Bay 61-3606 (50 mg/kg; administered twice a week for two weeks by intraperitoneal injection) alone leads to more efficacious reductions than that of TNF-related apoptosis-inducing ligand (TRAIL; 10 mg/kg) alone in MCF-7 tumor xenograft-bearing BALB/c nude mice. Bay 61-3606 administered in TRAIL combination significantly reduces the volume of the xenografted tumor[4].

Animal Model:Female BALB/c nude mice (5 weeks old) bearing MCF-7 tumor xenograft[4]
Dosage:50 mg/kg
Administration:Injected intraperitoneally twice a week with Bay 61-3606 (50 mg/kg), TRAIL (10 mg/kg) or a combination of Bay 61-3606 (50 mg/kg) and TRAIL (10 mg/kg); TRAIL was given 2 h after the injection of Bay 61-3606; for two weeks
Result:Led to efficacious reductions in tumor growth.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

BAY 61-3606(732983-37-8)MS
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