| Identification | Back Directory | [Name]
4-(3-CHLOROPHENYL)-ALPHA-(DIPHENYLMETHYL)-1-PIPERAZINEETHANOL HYDROCHLORIDE | [CAS]
734517-40-9 | [Synonyms]
BRL 15572
BRL 15572 (free base)
1-Piperazineethanol, 4-(3-chlorophenyl)-α-(diphenylmethyl)-
4-(3-Chlorophenyl)-α-(diphenylmethyl)-1-piperazineethanol hydrochloride
4-(3-CHLOROPHENYL)-ALPHA-(DIPHENYLMETHYL)-1-PIPERAZINEETHANOL HYDROCHLORIDE | [Molecular Formula]
C25H27ClN2O | [MDL Number]
MFCD02684402 | [MOL File]
734517-40-9.mol | [Molecular Weight]
406.95 |
| Hazard Information | Back Directory | [Uses]
BRL-15572 is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses[1]. | [Definition]
ChEBI: 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol is an N-alkylpiperazine that is 1-(3-chlorophenyl)piperazine carrying a 3,3-diphenyl-2-hydroxyprop-1-yl group at position 4. A selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types. It has a role as a serotonergic antagonist and a geroprotector. It is a N-alkylpiperazine, a N-arylpiperazine, a secondary alcohol and a member of monochlorobenzenes. It is a conjugate base of a 4-(3-chlorophenyl)-1-(2-hydroxy-3,3-diphenylpropyl)piperazin-1-ium(1+). | [References]
[1] Price GW, et, al. SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep; 356(3): 312-20. DOI:10.1007/pl00005056
[2] Geovanna NQ, et, al. Antinociceptive effect of (-)-epicatechin in inflammatory and neuropathic pain in rats. Behav Pharmacol. 2018 Apr; 29(2 and 3-Spec Issue): 270-279. DOI:10.1097/FBP.0000000000000320
[3] Hagan JJ, et, al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23; 331(2-3): 169-74. DOI:10.1016/s0014-2999(97)01055-8 |
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